DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and MASP1

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	323	Identity:	83/323 - (25%)
Similarity:	132/323 - (40%)	Gaps:	89/323 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 VYVCCPE-------LGDVLPN-KQTCGQTTP-----VFRDRGAENAELNEYPWMVLLLYEN---- 127
            :|.|..:       ||..||. ...|||.:.     |.|..|..|||...:||..|::.|:
Human   418 IYTCSAQGVWMNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRV 482

  Fly   128 ---------RLSLIRYVLTAAHCVIGGYLTQNDLVLKSVRLGESTTDCITSESRCPHLDVEVG-- 181
                     .|....::|||||            ||:|.| .::|...::.|    |:.|.:|
Human   483 PNDKWFGSGALLSASWILTAAH------------VLRSQR-RDTTVIPVSKE----HVTVYLGLH 530

  Fly   182 --------------QTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICL--LDAEFPLQDL 230
                          :..:|..|...  .|.:||||::||.||.....:.|:||  |:.|.|...:
Human   531 DVRDKSGAVNSSAARVVLHPDFNIQ--NYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHM 593

  Fly   231 NLQISGW---DPTKSSQTLITSTVKERNP------------ADCLNRYPSFRSA------SQVCA 274
            ...::||   :|..:...:|:|..:..:.            |:|...|.| ||.      :..||
Human   594 LGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYES-RSGNYSVTENMFCA 657

  Fly   275 GGQRKG-DTCAGISGSPVMGIMGSGVDEFVFLAGIASY-GQQYCYSAGIPGVYTKIGHFSEWI 335
            |....| |||.|.||...  ::...:.:...:.|:.|: |.:.|.|..:.|||||:.::.:|:
Human   658 GYYEGGKDTCLGDSGGAF--VIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	1/3 (33%)
		Tryp_SPc	108..338	CDD:238113	72/282 (26%)
		Tryp_SPc	108..335	CDD:214473	71/280 (25%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512
		CCP	374..439	CDD:153056	6/20 (30%)
		Tryp_SPc	456..718	CDD:214473	72/283 (25%)
		Tryp_SPc	457..718	CDD:238113	71/282 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910