DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and PRSS3

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_011516267.1	Gene:	PRSS3 / 5646	HGNCID:	9486	Length:	333	Species:	Homo sapiens

Alignment Length:	268	Identity:	76/268 - (28%)
Similarity:	105/268 - (39%)	Gaps:	41/268 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 DVLP--NKQTCGQTTPVFRDR---GAENAELNEYPWMVLLLYENRL---SLI--RYVLTAAHCVI 143
            |.||  |:...|...|...|.   |....|.|..|:.|.|...:..   |||  ::|::||||
Human    88 DYLPIRNQNELGVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHC-- 150

  Fly   144 GGYLTQNDLVLKSVRLGESTTDCITSESRCPHLDVEVGQTTVHQGFTSSGGTYRNDIALLRLQFP 208
              |.|:     ..|||||.....:....:.    :...:...|..:...  |..|||.|::|..|
Human   151 --YKTR-----IQVRLGEHNIKVLEGNEQF----INAAKIIRHPKYNRD--TLDNDIMLIKLSSP 202

  Fly   209 VRYTKKIQPICLLDAEFPLQDLNLQISGWDPTKSSQTLITSTVK-----ERNPADCLNRYPSFRS 268
            .....::..|.|.... |.......||||..|.|........:|     ....|:|...||...:
Human   203 AVINARVSTISLPTTP-PAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKIT 266

  Fly   269 ASQVCAGGQRKG-DTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFS 332
            .|..|.|....| |:|...||.||: ..|.       |.|:.|:|.. |.....||||||:.::.
Human   267 NSMFCVGFLEGGKDSCQRDSGGPVV-CNGQ-------LQGVVSWGHG-CAWKNRPGVYTKVYNYV 322

  Fly   333 EWIKANLA 340
            :|||..:|
Human   323 DWIKDTIA 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	68/240 (28%)
		Tryp_SPc	108..335	CDD:214473	65/237 (27%)
PRSS3	XP_011516267.1	Tryp_SPc	109..325	CDD:214473	65/240 (27%)
PRSS3	XP_011516267.1	Tryp_SPc	110..328	CDD:238113	68/242 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910