DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and PROC

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_024308770.1	Gene:	PROC / 5624	HGNCID:	9451	Length:	576	Species:	Homo sapiens

Alignment Length:	348	Identity:	101/348 - (29%)
Similarity:	152/348 - (43%)	Gaps:	84/348 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 PRGMTQAEKDVFAHRQCGLDPNG--HELLHMV----YVCCP--ELGDVLPN-----KQTCG---- 98
            ||....||   .:...|.||..|  |..|..|    ..|.|  :|||.|..     |..||
Human   242 PRPPLPAE---VSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWK 303

  Fly    99 ----QTTPVFRDRGAENAELN------------EYPWMVLLL-YENRLS----LIR--YVLTAAH 140
                :.:.:.||...:..:::            :.||.|:|| .:.:|:    ||.  :||||||
Human   304 RMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAH 368

  Fly   141 CVIGGYLTQNDLVLKSVRLGESTTDCITSESRCPHLDVEVGQTTVHQGFTSSGGTYRNDIALLRL 205
            |     :.::..:|  |||||  .|....|..  .||:::.:..||..::.|  |..||||||.|
Human   369 C-----MDESKKLL--VRLGE--YDLRRWEKW--ELDLDIKEVFVHPNYSKS--TTDNDIALLHL 420

  Fly   206 QFPVRYTKKIQPICLLDAEFPLQDLN-----LQISGW-------DPTKSSQTLITSTVK----ER 254
            ..|...::.|.||||.|:....::||     ..::||       ...|.::|.:.:.:|    ..
Human   421 AQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPH 485

  Fly   255 NPADCLNRYPSFRSASQVCAG--GQRKGDTCAGISGSP-VMGIMGSGVDEFVFLAGIASYGQQYC 316
            |  :|.....:..|.:.:|||  |.|: |.|.|.||.| |....|:.     ||.|:.|:|:. |
Human   486 N--ECSEVMSNMVSENMLCAGILGDRQ-DACEGDSGGPMVASFHGTW-----FLVGLVSWGEG-C 541

  Fly   317 YSAGIPGVYTKIGHFSEWIKANL 339
            ......|||||:..:.:||..::
Human   542 GLLHNYGVYTKVSRYLDWIHGHI 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	11/38 (29%)
		Tryp_SPc	108..338	CDD:238113	79/267 (30%)
		Tryp_SPc	108..335	CDD:214473	77/264 (29%)
PROC	XP_024308770.1	GLA	117..168	CDD:214503
		EGF_CA	182..213	CDD:238011
		FXa_inhibition	255..290	CDD:317114	13/34 (38%)
		Tryp_SPc	328..563	CDD:238113	79/256 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910