DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and habp2

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001103843.2	Gene:	habp2 / 553472	ZFINID:	ZDB-GENE-030131-4721	Length:	546	Species:	Danio rerio

Alignment Length:	348	Identity:	86/348 - (24%)
Similarity:	136/348 - (39%)	Gaps:	67/348 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VSCSPLMNILRPRGMTQAEKDVFAHRQCGLDPNGHE----------LLHMVYVCCPELGDVLPNK 94
            :.|.|..:.|.|....:..:.:..|..| .:|:|..          .|...|.......:..|.|
Zfish   215 IECLPWNHNLIPYKEFEGNESIGEHNYC-RNPDGDREPWCFVKEKGKLQWNYCNVKPCSETEPEK 278

  Fly    95 QTCGQTTPVFRDRGAENAEL-------------NEYPWMVLL---------LYENRL--SLIR-- 133
            .....|...|.|.|.....:             ..:||....         .:|:..  :||.
Zfish   279 PLTTPTKLEFSDCGKAAFSMIAPRIFGGRKSLPEAHPWQASFQVRPKGSNATFEHNCGGTLIDSC 343

  Fly   134 YVLTAAHCVIGGYLTQNDLVLKSVRLGESTTDCITSESRCPHLD-VEVGQTTVHQGFTSSGGTYR 197
            ::||||||:     .:||.|  .|.||.     :..|...|... |||.:..||:.:|.:.....
Zfish   344 WILTAAHCI-----DENDEV--RVELGG-----VNLEKDDPDKQFVEVEKIIVHENYTETFDALY 396

  Fly   198 NDIALLRLQFP----VRYTKKIQPICLLDAEFPLQDLNLQISGWDPTKS----SQTLITSTVKER 254
            ||||||:|:..    ...::.::..||....|| :.....|||:..|:.    |..|:.:.|...
Zfish   397 NDIALLKLKGRNGRCANESRSVRAACLPTDLFP-EGTRCTISGYGATEKHHGVSTQLLDAKVLLI 460

  Fly   255 NPADCLNR--YPSFRSASQVCAG-GQRKGDTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQYC 316
            :.:.|::|  |.:....|.:||| .|.|.|:|.|.||.|::    ...|...::.|:.|:|.. |
Zfish   461 SQSRCMSRNVYGNRMDDSMMCAGYMQGKIDSCQGDSGGPLV----CKKDNIHYIYGVVSWGDS-C 520

  Fly   317 YSAGIPGVYTKIGHFSEWIKANL 339
            .....||||.::..|.:||...:
Zfish   521 GKKNKPGVYARVTKFIDWINEKM 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	10/53 (19%)
		Tryp_SPc	108..338	CDD:238113	71/267 (27%)
		Tryp_SPc	108..335	CDD:214473	69/264 (26%)
habp2	NP_001103843.2	EGF_CA	80..112	CDD:238011
		EGF_CA	158..190	CDD:238011
		KR	195..273	CDD:214527	10/58 (17%)
		Tryp_SPc	302..539	CDD:214473	68/254 (27%)
		Tryp_SPc	303..542	CDD:238113	70/256 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910