DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and PLAT

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_000921.1	Gene:	PLAT / 5327	HGNCID:	9051	Length:	562	Species:	Homo sapiens

Alignment Length:	343	Identity:	91/343 - (26%)
Similarity:	142/343 - (41%)	Gaps:	109/343 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 HRQCGLDPNG------HELLH--MVYVCCPELGDVLPNKQTCG---QTTPVFRDRGAENAELNEY 117
            |..| .:|:|      |.|.:  :.:..|    || |:..|||   .:.|.||.:|...|::..:
Human   264 HNYC-RNPDGDAKPWCHVLKNRRLTWEYC----DV-PSCSTCGLRQYSQPQFRIKGGLFADIASH 322

  Fly   118 PWMVLLLYENRLS----------LIR--YVLTAAHCVIGGYLTQNDLVLKSVRLGESTTDCITSE 170
            ||...:..::|.|          ||.  ::|:||||.                           :
Human   323 PWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCF---------------------------Q 360

  Fly   171 SRCP--HLDVEVGQT-----------------TVHQGFTSSGGTYRNDIALLRLQFP----VRYT 212
            .|.|  ||.|.:|:|                 .||:.|...  ||.||||||:|:..    .:.:
Human   361 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDD--TYDNDIALLQLKSDSSRCAQES 423

  Fly   213 KKIQPICLLDAEFPLQD-LNLQISGWDPTKSSQTLITSTVKERNPADCLNRYPSFRSASQ----- 271
            ..::.:||..|:..|.| ...::||:...::.....:..:||.:    :..|||.|..||
Human   424 SVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAH----VRLYPSSRCTSQHLLNR 484

  Fly   272 ------VCAGGQRKG-------DTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPG 323
                  :|||..|.|       |.|.|.||.|::.:.    |..:.|.||.|:|.. |....:||
Human   485 TVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLN----DGRMTLVGIISWGLG-CGQKDVPG 544

  Fly   324 VYTKIGHFSEWIKANLAP 341
            ||||:.::.:||:.|:.|
Human   545 VYTKVTNYLDWIRDNMRP 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	6/27 (22%)
		Tryp_SPc	108..338	CDD:238113	73/283 (26%)
		Tryp_SPc	108..335	CDD:214473	71/280 (25%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:306546	10/37 (27%)
		Tryp_SPc	313..559	CDD:238113	73/283 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910