DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and KLKB1

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	345	Identity:	97/345 - (28%)
Similarity:	142/345 - (41%)	Gaps:	80/345 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CQKDEKCTRLVSCSPLMNILRPRGMTQAEKDVFAHRQCGLDP----------NGHELLHMVYVCC 84
            ||  |.||:::.|......|.|....:.:...|........|          :|:.|    .:|
Human   329 CQ--ETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSL----RLC- 386

  Fly    85 PELGDVLPNKQTCGQTTPVFRDRGAENAELNEYPW----MVLLLYENRL---SLI--RYVLTAAH 140
             ..||    ...|...|.. |..|..|:...|:||    .|.|..:..|   |||  ::||||||
Human   387 -NTGD----NSVCTTKTST-RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAH 445

  Fly   141 CVIGGYLTQNDLVLKSV--------RLGESTTDCITSESRCPHLDVEVGQTTVHQGFTSSGGTYR 197
            |..|       |.|:.|        .|.:.|.|...|         ::.:..:||.:..|.|.:
Human   446 CFDG-------LPLQDVWRIYSGILNLSDITKDTPFS---------QIKEIIIHQNYKVSEGNH- 493

  Fly   198 NDIALLRLQFPVRYTKKIQPICLLDAEFPLQD------LNLQISGWDPTKSSQTLITSTVKERNP 256
             ||||::||.|:.||:..:||||     |.:.      .|..::||..:|....:.....|...|
Human   494 -DIALIKLQAPLNYTEFQKPICL-----PSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIP 552

  Fly   257 ----ADCLNRYPSFR-SASQVCAGGQRKG-DTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQY 315
                .:|..||..:: :...||||.:..| |.|.|.||.|:: ...:|:..   |.||.|:|:.
Human   553 LVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLV-CKHNGMWR---LVGITSWGEG- 612

  Fly   316 CYSAGIPGVYTKIGHFSEWI 335
            |.....||||||:..:.:||
Human   613 CARREQPGVYTKVAEYMDWI 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	9/58 (16%)
		Tryp_SPc	108..338	CDD:238113	79/257 (31%)
		Tryp_SPc	108..335	CDD:214473	77/255 (30%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519	12/62 (19%)
		Tryp_SPc	401..632	CDD:214473	78/258 (30%)
		Tryp_SPc	402..632	CDD:238113	77/257 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910