DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and PRSS48

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_011530223.1	Gene:	PRSS48 / 345062	HGNCID:	24635	Length:	351	Species:	Homo sapiens

Alignment Length:	276	Identity:	76/276 - (27%)
Similarity:	118/276 - (42%)	Gaps:	59/276 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 CGQTTPVFRDR--GAENAELNEYPWMVLLLYENRL----SLI--RYVLTAAHCVIGGYLTQNDLV 153
            |||  ||:..|  |.::|....:||.|.|.:::..    ||:  |.:||||||:...:.|.:..|
Human    42 CGQ--PVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFSYTV 104

  Fly   154 -LKSVRLGESTTDCITSESRCPHLDVEVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQP 217
             |.|:.:|:|.          ..:...|.:..:|..:..:..    |:|||:|...|.:|..|.|
Human   105 WLGSITVGDSR----------KRVKYYVSKIVIHPKYQDTTA----DVALLKLSSQVTFTSAILP 155

  Fly   218 ICLLDAEFPLQDLNLQI------SGWDPTKSS------QTLITSTVKERNPADCLNRY------- 263
            |||     |.....|.|      :||...|.|      ..|..:.|...:...|...|
Human   156 ICL-----PSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFL 215

  Fly   264 PSFR---SASQVCAGG-QRKGDTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGV 324
            |:..   ...::|||. |...|:|.|.||.|    :...:|......|:.|:|.: | ...:|||
Human   216 PALEPVIKEDKICAGDTQNMKDSCKGDSGGP----LSCHIDGVWIQTGVVSWGLE-C-GKSLPGV 274

  Fly   325 YTKIGHFSEWIKANLA 340
            ||.:.::.:||.|.::
Human   275 YTNVIYYQKWINATIS 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	69/259 (27%)
		Tryp_SPc	108..335	CDD:214473	67/256 (26%)
PRSS48	XP_011530223.1	Tryp_SPc	50..285	CDD:214473	68/259 (26%)
PRSS48	XP_011530223.1	Tryp_SPc	51..288	CDD:238113	69/261 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910