DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and OVCH1

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_024304736.1	Gene:	OVCH1 / 341350	HGNCID:	23080	Length:	1120	Species:	Homo sapiens

Alignment Length:	316	Identity:	84/316 - (26%)
Similarity:	126/316 - (39%)	Gaps:	72/316 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LRPRGMTQAEKDVFAHRQCGLDPNGHELLHMVYVCCPELGDVLPNKQTCGQTTPVFRDRGAENAE 113
            |.|:....:......|..||:.|...:.|..                         |..|.|.|.
Human   578 LPPQNNPVSTVKAILHDVCGIPPFSPQWLSR-------------------------RIAGGEEAC 617

  Fly   114 LNEYPWMVLLL----YENRLSLIR--YVLTAAHCVIGGYLTQNDLVLKSV------RLGESTTDC 166
            .:.:||.|.|.    |:...::|.  ::|||||||   .|..|.|....:      .|.|||...
Human   618 PHCWPWQVGLRFLGDYQCGGAIINPVWILTAAHCV---QLKNNPLSWTIIAGDHDRNLKESTEQV 679

  Fly   167 ITSESRCPHLDVEVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAEFPLQDLN 231
                .|..|:       .||:.|.:.  :|.:||||::|..|:.|...::|:||..:..||....
Human   680 ----RRAKHI-------IVHEDFNTL--SYDSDIALIQLSSPLEYNSVVRPVCLPHSAEPLFSSE 731

  Fly   232 L-QISGWDPTKSSQTL------ITSTVKERNPADCLNRY----PSFRSASQVCAGGQRKG--DTC 283
            : .::||....:...|      |...|.||..  |.:.|    |...:...:|||....|  |.|
Human   732 ICAVTGWGSISADGGLASRLQQIQVHVLEREV--CEHTYYSAHPGGITEKMICAGFAASGEKDFC 794

  Fly   284 AGISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIKANL 339
            .|.||.|::....:|  .|| |.||.|:|.. |.....|||:.::..|.:||::.:
Human   795 QGDSGGPLVCRHENG--PFV-LYGIVSWGAG-CVQPWKPGVFARVMIFLDWIQSKI 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	7/34 (21%)
		Tryp_SPc	108..338	CDD:238113	76/254 (30%)
		Tryp_SPc	108..335	CDD:214473	74/251 (29%)
OVCH1	XP_024304736.1	Tryp_SPc	58..294	CDD:238113
		CUB	336..444	CDD:238001
		CUB	454..565	CDD:238001
		Tryp_SPc	610..845	CDD:238113	76/256 (30%)
		CUB	881..978	CDD:238001
		CUB	1017..1119	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910