DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and OVCH2

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_016873148.1	Gene:	OVCH2 / 341277	HGNCID:	29970	Length:	569	Species:	Homo sapiens

Alignment Length:	308	Identity:	79/308 - (25%)
Similarity:	117/308 - (37%)	Gaps:	95/308 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LPNKQTCGQTT---------PVF-RDRGAENAELNEYPWMVLLLYENRL----SLI--RYVLTAA 139
            ||...:|||:.         .:| |..|....|...|||.|.|....:.    |::  ::|:|||
Human    31 LPKAPSCGQSLVKVQPWNYFNIFSRILGGSQVEKGSYPWQVSLKQRQKHICGGSIVSPQWVITAA 95

  Fly   140 HCVIGGYLTQNDLVLKSVRLGE---STTD----CITSESRCPHLDVEVGQTTVHQGF-TSSGGTY 196
            ||:    ..:|.:...:|..||   |.||    .:|.|:           ..:|..| |.....|
Human    96 HCI----ANRNIVSTLNVTAGEYDLSQTDPGEQTLTIET-----------VIIHPHFSTKKPMDY 145

  Fly   197 RNDIALLRLQFPVRYTKKIQPICL------LDAEF------------------PLQDLNLQISGW 237
              |||||::....::...:.||||      .:|.|                  .||::||.|..|
Human   146 --DIALLKMAGAFQFGHFVGPICLPELREQFEAGFICTTAGWGRLTEGGVLSQVLQEVNLPILTW 208

  Fly   238 DPTKSSQTLITSTVKERNPADCLNRYPSFRSASQVCAGGQRKG-DTCAGISGSPVMGIMGSGVDE 301
            :...::  |:|           |.|..|.::.  :|.|....| |.|.|.||..:|.....|.
Human   209 EECVAA--LLT-----------LKRPISGKTF--LCTGFPDGGRDACQGDSGGSLMCRNKKGA-- 256

  Fly   302 FVFLAGIASYGQQYC----------YSAGIPGVYTKIGHFSEWIKANL 339
             ..|||:.|:|.. |          ...|.||::|.|.....||..::
Human   257 -WTLAGVTSWGLG-CGRGWRNNVRKSDQGSPGIFTDISKVLPWIHEHI 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	72/278 (26%)
		Tryp_SPc	108..335	CDD:214473	70/275 (25%)
OVCH2	XP_016873148.1	Tryp_SPc	55..298	CDD:214473	71/278 (26%)
		Tryp_SPc	56..301	CDD:238113	72/280 (26%)
		CUB	320..424	CDD:238001
		CUB	435..546	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910