DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18754 and HABP2

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_004123.1	Gene:	HABP2 / 3026	HGNCID:	4798	Length:	560	Species:	Homo sapiens

Alignment Length:	296	Identity:	86/296 - (29%)
Similarity:	117/296 - (39%)	Gaps:	83/296 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LPNKQTCGQT----TPVFRDRGAENAELNEYPWMVLLLYENRLSLIR--------------YVLT 137
            ||...:||:|    ..:.|..|...:...::||...|.....|::..              :|||
Human   295 LPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLT 359

  Fly   138 AAHCVIGGYLTQNDLVLKSVRLGESTTDCITSESRCPHLDVEVGQT------------TVHQGFT 190
            ||||                      ||..|.     ||.|.:|..            .|.:.|.
Human   360 AAHC----------------------TDIKTR-----HLKVVLGDQDLKKEEFHEQSFRVEKIFK 397

  Fly   191 SSGGTYR-----NDIALLRLQFPV-----RYTKKIQPICLLDAEFPLQDLNLQISGWDPT---KS 242
            .|....|     ||||||:|: ||     ..:|.::.:||.|..|| ......||||..|   |.
Human   398 YSHYNERDEIPHNDIALLKLK-PVDGHCALESKYVKTVCLPDGSFP-SGSECHISGWGVTETGKG 460

  Fly   243 SQTLITSTVKERNPADCLNR--YPSFRSASQVCAGG-QRKG-DTCAGISGSPVMGIMGSGVDEFV 303
            |:.|:.:.||......|.:|  |......|.:|||. |:.| |||.|.||.|    :....|...
Human   461 SRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGP----LTCEKDGTY 521

  Fly   304 FLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIKANL 339
            ::.||.|:|.: |...  |||||::..|..||||.:
Human   522 YVYGIVSWGLE-CGKR--PGVYTQVTKFLNWIKATI 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	79/272 (29%)
		Tryp_SPc	108..335	CDD:214473	76/269 (28%)
HABP2	NP_004123.1	EGF	77..106	CDD:306513
		KR	191..277	CDD:238056
		Tryp_SPc	314..553	CDD:238113	79/274 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910