DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and GZMH

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_219491.1	Gene:	GZMH / 2999	HGNCID:	4710	Length:	246	Species:	Homo sapiens

Alignment Length:	252	Identity:	67/252 - (26%)
Similarity:	110/252 - (43%)	Gaps:	51/252 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 GAENAELNEYPWMVLLLYENRLS-------LIR--YVLTAAHCVIGGYLTQNDLVLKSVRLGEST 163
            |...|:.:..|:|..:.:....|       |:|  :|||||||       |...:  :|.||...
Human    23 GGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLTAAHC-------QGSSI--NVTLGAHN 78

  Fly   164 TDCITSESRCPHLDVEVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAEFPLQ 228
               |..:.|.... :.|.:...|..:...  .:.|||.||:|:...::|..::|:.|..::..::
Human    79 ---IKEQERTQQF-IPVKRPIPHPAYNPK--NFSNDIMLLQLERKAKWTTAVRPLRLPSSKAQVK 137

  Fly   229 DLNL-QISGWDPTKSSQTLITS------TVKERNPADCLNR---YPSFRSASQVCAGGQRKGDT- 282
            ...| .::||... |..||.|:      ||::    ||...   :.::..|:::|.|..:|..|
Human   138 PGQLCSVAGWGYV-SMSTLATTLQEVLLTVQK----DCQCERLFHGNYSRATEICVGDPKKTQTG 197

  Fly   283 CAGISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIKANL 339
            ..|.||.|   ::...|.:     ||.|||.:   ....||||.|:.||..|||..:
Human   198 FKGDSGGP---LVCKDVAQ-----GILSYGNK---KGTPPGVYIKVSHFLPWIKRTM 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	67/249 (27%)
		Tryp_SPc	108..335	CDD:214473	64/246 (26%)
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	67/249 (27%)
GZMH	NP_219491.1	Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910