DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and Klk8

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001311327.1	Gene:	Klk8 / 259277	MGIID:	1343327	Length:	260	Species:	Mus musculus

Alignment Length:	253	Identity:	82/253 - (32%)
Similarity:	113/253 - (44%)	Gaps:	41/253 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 RDRGAENAELNE-----YPWMVLLLYENRL----SLI--RYVLTAAHCVIGGYLTQNDLVLKSVR 158
            |.:|::..|..|     .||...|....||    .|:  |:|||||||....|         |||
Mouse    27 RAQGSKILEGRECIPHSQPWQAALFQGERLICGGVLVGDRWVLTAAHCKKQKY---------SVR 82

  Fly   159 LGESTTDCITSESR-CPHLDVEVGQTTVHQGFTSSG-GTYRNDIALLRLQFPVRYTKKIQPICLL 221
            ||:.:.     :|| .|..:::|.|:..|..:.:|. ..:.:||.|:|||.......|::|:.|.
Mouse    83 LGDHSL-----QSRDQPEQEIQVAQSIQHPCYNNSNPEDHSHDIMLIRLQNSANLGDKVKPVQLA 142

  Fly   222 DAEFPLQDLNLQISGWDPTKSSQ-----TLITSTVKERNPADCLNRYPSFRSASQVCAGGQRKGD 281
            :. .|.......||||....|.|     ||..:.||..:...|...||...:...||||.....|
Mouse   143 NL-CPKVGQKCIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPGKITEGMVCAGSSNGAD 206

  Fly   282 TCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIKANL 339
            ||.|.||.|   ::..|:     |.||.|:|...|.....|||||||..::.|||..:
Mouse   207 TCQGDSGGP---LVCDGM-----LQGITSWGSDPCGKPEKPGVYTKICRYTTWIKKTM 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	81/247 (33%)
		Tryp_SPc	108..335	CDD:214473	78/244 (32%)
Klk8	NP_001311327.1	Tryp_SPc	32..252	CDD:214473	77/242 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910