DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and F11

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_005262878.1	Gene:	F11 / 2160	HGNCID:	3529	Length:	626	Species:	Homo sapiens

Alignment Length:	367	Identity:	90/367 - (24%)
Similarity:	132/367 - (35%)	Gaps:	123/367 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SCQKDEKCTRLVSC----------------------------SPLMNILRPRGMTQAEKDVFAHR 65
            :|||  .||..|.|                            || ..||..||....    :..|
Human   316 ACQK--LCTNAVRCQFFTYTPAQASCNEGNRGKCYLKLSSNGSP-TKILHGRGGISG----YTLR 373

  Fly    66 QCGLDPNGHELLHMVYVCCPELGDVLPNKQTCGQTTPVFRDRGAENAELNEYPWMVLLLYENRL- 129
            .|.:|..          |..::     ..:..|.|..|   ||       |:||.|.|...:..
Human   374 LCKMDNE----------CTTKI-----KPRIVGGTASV---RG-------EWPWQVTLHTTSPTQ 413

  Fly   130 ------SLI--RYVLTAAHCVIG-----------GYLTQNDLVLKSVRLGESTTDCITSESRCPH 175
                  |:|  :::||||||..|           |.|.|:::...:...|
Human   414 RHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFG--------------- 463

  Fly   176 LDVEVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAEFPLQ-DLNL-----QI 234
                |.:..:|..:..:...|  |||||:|:..|.||...:||||     |.: |.|:     .:
Human   464 ----VQEIIIHDQYKMAESGY--DIALLKLETTVNYTDSQRPICL-----PSKGDRNVIYTDCWV 517

  Fly   235 SGWDPTKSSQTLITSTVKERNP----ADCLNRYPSFRSASQVCAGGQRKG--DTCAGISGSPVMG 293
            :||...|....:..:..|.:.|    .:|..||...:...::...|.|:|  |.|.|.||.|
Human   518 TGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGP--- 579

  Fly   294 IMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWI 335
             :....:|...|.||.|:|:. |.....|||||.:..:.:||
Human   580 -LSCKHNEVWHLVGITSWGEG-CAQRERPGVYTNVVEYVDWI 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	13/76 (17%)
		Tryp_SPc	108..338	CDD:238113	69/260 (27%)
		Tryp_SPc	108..335	CDD:214473	67/258 (26%)
F11	XP_005262878.1	APPLE	20..103	CDD:128519
		APPLE	110..193	CDD:128519
		APPLE	200..283	CDD:128519
		APPLE	291..375	CDD:128519	14/65 (22%)
		Tryp_SPc	388..619	CDD:214473	71/271 (26%)
		Tryp_SPc	389..619	CDD:238113	71/270 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910