DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18754 and F10

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	416	Identity:	100/416 - (24%)
Similarity:	151/416 - (36%)	Gaps:	122/416 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FFNQLA---ECVRLSSCQKDEKCTRLV---SCSPLMNILRPRGMTQAEKDVFAHRQCGLDPNG-- 73
            |:|:..   :| ..|.||...||...:   :|:.|      .|......::|..:.|.|| ||
Human    80 FWNKYKDGDQC-ETSPCQNQGKCKDGLGEYTCTCL------EGFEGKNCELFTRKLCSLD-NGDC 136

  Fly    74 ----HELLHMVYVCCPELGDVLPNKQTC------------------------------------- 97
                ||..:.|...|.....:..|.:.|
Human   137 DQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWK 201

  Fly    98 -------------------GQTTPVFRDR------GAENAELNEYPWMVLLLYENR--------L 129
                               .||.|...|.      |.:..:..|.||..||:.|..        |
Human   202 PYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTIL 266

  Fly   130 SLIRYVLTAAHCVIGGYLTQNDLVLKSVRLGESTTDCITSESRCPHLDVEVGQTTVHQGFTSSGG 194
            |.. |:||||||:   |..:.    ..||:|:..|:  ..|......:|||  ...|..||..
Human   267 SEF-YILTAAHCL---YQAKR----FKVRVGDRNTE--QEEGGEAVHEVEV--VIKHNRFTKE-- 317

  Fly   195 TYRNDIALLRLQFPVRYTKKIQPICLLDAEFPLQDLNLQ----ISGWDPT--KSSQT----LITS 249
            ||..|||:|||:.|:.:...:.|.||.:.::....|..|    :||:..|  |..|:    ::..
Human   318 TYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEV 382

  Fly   250 TVKERNPADCLNRYPSFRSASQVCAG-GQRKGDTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQ 313
            ...:||  .|........:.:..||| ..::.|.|.|.||.|.:    :...:..|:.||.|:|:
Human   383 PYVDRN--SCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHV----TRFKDTYFVTGIVSWGE 441

  Fly   314 QYCYSAGIPGVYTKIGHFSEWIKANL 339
            . |...|..|:|||:..|.:||..::
Human   442 G-CARKGKYGIYTKVTAFLKWIDRSM 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	14/57 (25%)
		Tryp_SPc	108..338	CDD:238113	73/248 (29%)
		Tryp_SPc	108..335	CDD:214473	71/245 (29%)
F10	NP_000495.1	GLA	25..85	CDD:214503	2/4 (50%)
		EGF_CA	86..122	CDD:238011	9/42 (21%)
		FXa_inhibition	129..164	CDD:317114	10/35 (29%)
		O-glycosylated at one site	183..203		0/19 (0%)
		Tryp_SPc	235..464	CDD:238113	73/249 (29%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920