DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and F2

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_000497.1	Gene:	F2 / 2147	HGNCID:	3535	Length:	622	Species:	Homo sapiens

Alignment Length:	376	Identity:	91/376 - (24%)
Similarity:	147/376 - (39%)	Gaps:	115/376 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LSSCQK----------DEKCTRLV----SCSPLMNILRPRGMTQAEKDVFAHRQCGL-------- 69
            |:.|::          ||...|.:    :.|.......||.....|.|      |||
Human   288 LNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEAD------CGLRPLFEKKS 346

  Fly    70 --DPNGHELLHMVYVCCPELGDVLPNKQTCGQTTPVFRDRGAENAELNEYPWMVLLLYENRLSLI 132
              |....|||.. |:.    |.::.                ..:||:...||.|:|..::...|:
Human   347 LEDKTERELLES-YID----GRIVE----------------GSDAEIGMSPWQVMLFRKSPQELL 390

  Fly   133 --------RYVLTAAHCVIGGY------LTQNDLVLKSVRLGE-STTDCITSESRCPHLDVEVGQ 182
                    |:|||||||::  |      .|:|||:   ||:|: |.|....:..:...|:    :
Human   391 CGASLISDRWVLTAAHCLL--YPPWDKNFTENDLL---VRIGKHSRTRYERNIEKISMLE----K 446

  Fly   183 TTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAEFPLQDLNL----QISGWDPTKSS 243
            ..:|..:.......| ||||::|:.||.::..|.|:||.|.|.....|..    :::||...|.:
Human   447 IYIHPRYNWRENLDR-DIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKET 510

  Fly   244 QT------------LITSTVKERNPADCLNRYPSFRSASQV-------CAGGQ----RKGDTCAG 285
            .|            ::...:.||         |..:.::::       |||.:    ::||.|.|
Human   511 WTANVGKGQPSVLQVVNLPIVER---------PVCKDSTRIRITDNMFCAGYKPDEGKRGDACEG 566

  Fly   286 ISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIK 336
            .||.|.  :|.|..:...:..||.|:|:. |...|..|.||.:....:||:
Human   567 DSGGPF--VMKSPFNNRWYQMGIVSWGEG-CDRDGKYGFYTHVFRLKKWIQ 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	14/62 (23%)
		Tryp_SPc	108..338	CDD:238113	72/271 (27%)
		Tryp_SPc	108..335	CDD:214473	70/268 (26%)
F2	NP_000497.1	GLA	25..88	CDD:214503
		KR	105..186	CDD:238056
		KR	211..293	CDD:214527	2/4 (50%)
		Thrombin_light	317..363	CDD:286482	13/56 (23%)
		Tryp_SPc	363..613	CDD:214473	70/287 (24%)
		Tryp_SPc	364..616	CDD:238113	72/289 (25%)
		High affinity receptor-binding region which is also known as the TP508 peptide	551..573		9/23 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910