DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and PRSS55

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_940866.2	Gene:	PRSS55 / 203074	HGNCID:	30824	Length:	352	Species:	Homo sapiens

Alignment Length:	261	Identity:	74/261 - (28%)
Similarity:	119/261 - (45%)	Gaps:	38/261 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 CGQTTPVFRDR-------GAENAELNEYPWMVLLLYENRL----SLIR--YVLTAAHCVIGGYLT 148
            ||..: :|..|       |...||:.|:||.|.:...:..    |::.  ::||||||:....|.
Human    53 CGDRS-IFEGRTRYSRITGGMEAEVGEFPWQVSIQARSEPFCGGSILNKWWILTAAHCLYSEELF 116

  Fly   149 QNDLVLKSVRLGESTTDCITSESRCPHLDV-EVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYT 212
            ..:|   ||.||   |:.:||    |.::: ||....:|:.|..:  ...||||||.|..|::..
Human   117 PEEL---SVVLG---TNDLTS----PSMEIKEVASIILHKDFKRA--NMDNDIALLLLASPIKLD 169

  Fly   213 KKIQPICLLDAEFPLQDLNLQISGWDPTKSSQTLITSTVKERNP------ADCLNRYPSFRSASQ 271
            ....||||.....|.......::||..|.::......|...:.|      .:|...:|.. :.:.
Human   170 DLKVPICLPTQPGPATWRECWVAGWGQTNAADKNSVKTDLMKAPMVIMDWEECSKMFPKL-TKNM 233

  Fly   272 VCAGGQRKG-DTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWI 335
            :|||.:.:. |.|.|.||.|::.....|  |..:..||.|:|:. |.....||:||.:.:::.||
Human   234 LCAGYKNESYDACKGDSGGPLVCTPEPG--EKWYQVGIISWGKS-CGEKNTPGIYTSLVNYNLWI 295

  Fly   336 K 336
            :
Human   296 E 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	70/243 (29%)
		Tryp_SPc	108..335	CDD:214473	68/240 (28%)
PRSS55	NP_940866.2	Tryp_SPc	67..295	CDD:214473	68/243 (28%)
		Tryp_SPc	68..298	CDD:238113	70/245 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910