DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and CFD

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001304264.1	Gene:	CFD / 1675	HGNCID:	2771	Length:	260	Species:	Homo sapiens

Alignment Length:	297	Identity:	66/297 - (22%)
Similarity:	110/297 - (37%)	Gaps:	93/297 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 VLPNKQTCGQ------TTPVFRDRGAENAELNEYPWMVLL------LYENRLSLIRYVLTAAHC- 141
            ||.....||:      ..|..|..|...||.:..|:|..:      |....|...::||:||||
Human    11 VLLGAAACGEEAWAWAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCL 75

  Fly   142 ----------VIGGY-LTQNDL------VLKSVRLGESTTDCITSESRCPHLDVEVGQTTVHQGF 189
                      ::|.: |:|.:.      ||::|                ||.|
Human    76 EDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAV----------------PHPD------------ 112

  Fly   190 TSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAEFPLQDLN--------LQISGWD-------- 238
             |...|..:|:.||:|.........::|:       |.|.::        ..::||.
Human   113 -SQPDTIDHDLLLLQLSEKATLGPAVRPL-------PWQRVDRDVAPGTLCDVAGWGIVNHAGRR 169

  Fly   239 PTKSSQTLITSTVKERNPADCLNRYPSFRSASQVCAGGQRKGDTCAGISGSPVMGIMGSGVDEFV 303
            |......|:  .|.:|...:....:....:...:||...|: |:|.|.||.|   ::..||
Human   170 PDSLQHVLL--PVLDRATCNRRTHHDGAITERLMCAESNRR-DSCKGDSGGP---LVCGGV---- 224

  Fly   304 FLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIKANLA 340
             |.|:.:.|.:.|.:...||:||::..::.||.:.||
Human   225 -LEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	58/269 (22%)
		Tryp_SPc	108..335	CDD:214473	56/266 (21%)
CFD	NP_001304264.1	Tryp_SPc	32..255	CDD:214473	57/269 (21%)
CFD	NP_001304264.1	Tryp_SPc	33..258	CDD:238113	58/271 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910