DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and CTRB1

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001897.4	Gene:	CTRB1 / 1504	HGNCID:	2521	Length:	263	Species:	Homo sapiens

Alignment Length:	257	Identity:	67/257 - (26%)
Similarity:	102/257 - (39%)	Gaps:	59/257 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 ENAELNEYPWMVLLLYENRL-----SLIR--YVLTAAHC-------VIGGYLTQ-----NDLVLK 155
            |:|....:||.|.|..:...     |||.  :|:|||||       |:.|...|     |..|||
Human    38 EDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLK 102

  Fly   156 SVRLGESTTDCITSESRCPHLDVEVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICL 220
            ..::.::....|.                          |..|||.||:|..|.|:::.:..:||
Human   103 IAKVFKNPKFSIL--------------------------TVNNDITLLKLATPARFSQTVSAVCL 141

  Fly   221 --LDAEFPLQDLNLQISGWDPTKSSQTLITSTVKER-----NPADCLNRYPSFRSASQVCAGGQR 278
              .|.:||...| ...:||..||.:.......:::.     :.|:|...:....:...:|||...
Human   142 PSADDDFPAGTL-CATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAGASG 205

  Fly   279 KGDTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIKANLA 340
            . .:|.|.||.|::    ...|....|.||.|:|...| |...||||.::.....|::..||
Human   206 V-SSCMGDSGGPLV----CQKDGAWTLVGIVSWGSDTC-STSSPGVYARVTKLIPWVQKILA 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	65/253 (26%)
		Tryp_SPc	108..335	CDD:214473	64/250 (26%)
CTRB1	NP_001897.4	Tryp_SPc	33..256	CDD:214473	64/250 (26%)
CTRB1	NP_001897.4	Tryp_SPc	34..259	CDD:238113	65/253 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910