DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and TMPRSS11B

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_872308.2	Gene:	TMPRSS11B / 132724	HGNCID:	25398	Length:	416	Species:	Homo sapiens

Alignment Length:	235	Identity:	60/235 - (25%)
Similarity:	108/235 - (45%)	Gaps:	36/235 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 YPWMVLLLYENR----LSLI--RYVLTAAHCVIGGYLTQNDLVLKSVRLGESTTDCITSESRCPH 175
            :||...:.::.|    .|||  |::|:||||    :..:|:....:|..|     .:.::   |:
Human   196 WPWQASMQWKGRHYCGASLISSRWLLSAAHC----FAKKNNSKDWTVNFG-----IVVNK---PY 248

  Fly   176 LDVEVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAEFPL-QDLNLQISGWD- 238
            :..:|.....|:.::|.|  ..:||||::|...|.:|:.|:.|||.:|:..| ::.|:.::||.
Human   249 MTRKVQNIIFHENYSSPG--LHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWGT 311

  Fly   239 -------PTKSSQTLITSTVKERNPADCLNRYPSFRSASQVCAGGQR-KGDTCAGISGSPVMGIM 295
                   |....:..:  .:.:....:....|..|.:.:.:|||... :.|.|...||.|:....
Human   312 LYMNGSFPVILQEDFL--KIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPLAYPD 374

  Fly   296 GSGVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWI 335
            ...:   ..|.||.|:|.. |.....|||||::..:..||
Human   375 SRNI---WHLVGIVSWGDG-CGKKNKPGVYTRVTSYRNWI 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855
		Tryp_SPc	108..338	CDD:238113	60/235 (26%)
		Tryp_SPc	108..335	CDD:214473	58/233 (25%)
TMPRSS11B	NP_872308.2	SEA	45..143	CDD:279699
		Tryp_SPc	184..410	CDD:214473	58/233 (25%)
		Tryp_SPc	185..413	CDD:238113	60/235 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910