DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and CLIPB13

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_314336.2	Gene:	CLIPB13 / 1275070	VectorBaseID:	AGAP004855	Length:	410	Species:	Anopheles gambiae

Alignment Length:	393	Identity:	114/393 - (29%)
Similarity:	171/393 - (43%)	Gaps:	83/393 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RKVYILVLLQAIFFNQLAECVRLSSCQKDEKCTRLVSCSPLMNILRPRGMTQ---------AEKD 60
            |.:|.:::........:...:..::|...: ..|.|.|.||..:..|...|.         |...
Mosquito    45 RNIYSIIISPTPPSRGIQNYINRAACSLPD-VPRSVCCQPLEVVPAPTTTTTTTTTTTTTVAPST 108

  Fly    61 VFAHRQ--------CGLDPNGHELLHMVYVCCPELGDVLPNKQTCGQTTPVFRDRGAENAELNEY 117
            |.|..:        .|::|:....|:...:.....|.:..|:...|.||.||           ||
Mosquito   109 VVAPVKTNAGPVMVTGVEPDAGATLNWNLLPTRNCGTITVNRIAHGNTTRVF-----------EY 162

  Fly   118 PWMVLLLYENR--------LSLI--RYVLTAAHCVIGGYLTQNDLVLKSVRLGE----STTDC-- 166
            ||||||.||:.        .|||  ||||||||||    .|.:.:.|..|||||    ...||
Mosquito   163 PWMVLLRYESNGVLSDRCGGSLINNRYVLTAAHCV----RTSSSIRLVKVRLGEHDKRQQIDCHV 223

  Fly   167 -ITSESRC--PHLDVEVGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAEFPL- 227
             ...|..|  |.:||::....||:.: :....:|:||||||:...|.::..::||||     |:
Mosquito   224 YSDGEKDCADPAVDVDIESMIVHKDY-NRPIKFRHDIALLRMAQEVEFSDSVKPICL-----PVN 282

  Fly   228 QDLNLQ------ISGWDPTKS---SQTLITSTVKERNPADCLNR------YPSFRSASQVCAGGQ 277
            :|:..:      |:||..|:.   |..|:.:.|......:|..:      |.:.....|:||.|:
Mosquito   283 EDVRRKVLPKYIITGWGTTEQQSLSDLLLQAIVNHVPVPECQQKMNENFLYVTLADEWQMCAAGE 347

  Fly   278 RKGDTCAGISGSPVMGIMGSGVD----EFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIKAN 338
            ...|:|.|.||.|    :|..||    :||.. ||.|.|.:.|....:||:||::..:..||.||
Mosquito   348 GLVDSCQGDSGGP----LGFSVDVAGAKFVQF-GIVSAGVRSCGKESVPGIYTRVTSYMNWIVAN 407

  Fly   339 LAP 341
            :.|
Mosquito   408 MKP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	13/65 (20%)
		Tryp_SPc	108..338	CDD:238113	88/268 (33%)
		Tryp_SPc	108..335	CDD:214473	86/265 (32%)
CLIPB13	XP_314336.2	CLIP	28..81	CDD:288855	5/36 (14%)
		Tryp_SPc	150..404	CDD:214473	91/279 (33%)
		Tryp_SPc	151..404	CDD:238113	91/278 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24260
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020