DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and f7

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_571894.2	Gene:	f7 / 114423	ZFINID:	ZDB-GENE-010814-1	Length:	433	Species:	Danio rerio

Alignment Length:	364	Identity:	92/364 - (25%)
Similarity:	143/364 - (39%)	Gaps:	84/364 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SSCQKDEKCTR------LVSCSPLM--------------NILRPRGMTQ---AEKDVFAHRQCG- 68
            |.|:.|..||.      :..|:|..              :.|...|..:   .|:|  ..|.|.
Zfish    91 SPCEHDGLCTTQNADSYMCLCAPGFSGRHCEQSIGDVPDSCLHDNGGCEHFCTEQD--GRRNCSC 153

  Fly    69 -----LDPNGHEL-LHMVYVCCPELGDV---LPNKQTCGQTTPVFRDRGAENAELNEYPWMVLLL 124
                 ||..|.:. .|.|:.|    |.|   ...|....|.....|..|.........||.|||.
Zfish   154 ADGYYLDNGGQKCRSHEVFPC----GKVPLLQAGKAADHQVDLRSRIVGGSECPKGHCPWQVLLK 214

  Fly   125 YENR------LSLIRYVLTAAHCVIGGYLTQNDLVLKSVRLGESTTDCITSESRCPHLDVEVGQT 183
            |..:      :....::||||||:       ..|.:|.:|:.....|....|.  ....::|.|.
Zfish   215 YGEKGFCGGVIYKPTWILTAAHCL-------EKLKVKFLRIVAGEHDLEVDEG--TEQLIQVDQM 270

  Fly   184 TVHQGFTSSGGTYRNDIALLRLQFPVRYTKKIQPICLLDAEFPLQDL---------NLQISGWDP 239
            ..|..:.|.  |..:|||||||:.|:.|:....|:||     ||:::         ...:|||.
Zfish   271 FTHPAYVSE--TADSDIALLRLRTPIVYSVYAVPVCL-----PLREMAERELWAVSKHTVSGWG- 327

  Fly   240 TKSSQTLITSTVKER------NPADCLNRYPSFRSASQVCAGG-QRKGDTCAGISGSPVMGIMGS 297
             |.|:...||.:..|      ...:|:.......:::..|||. :.:.|:|.|.||.|::    :
Zfish   328 -KRSEDGPTSRLLRRLLVPRIRTQECVQVSNLTLTSNMFCAGYIEGRQDSCKGDSGGPLV----T 387

  Fly   298 GVDEFVFLAGIASYGQQYCYSAGIPGVYTKIGHFSEWIK 336
            ...:..||.||.|:|:. |...|..|:||::.::.:||:
Zfish   388 RYRDTAFLLGIVSWGKG-CARPGSYGIYTRVSNYLQWIR 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	15/78 (19%)
		Tryp_SPc	108..338	CDD:238113	68/251 (27%)
		Tryp_SPc	108..335	CDD:214473	66/248 (27%)
f7	NP_571894.2	GLA	19..82	CDD:214503
		EGF_CA	86..121	CDD:238011	7/29 (24%)
		FXa_inhibition	131..166	CDD:291342	9/36 (25%)
		Tryp_SPc	195..424	CDD:214473	67/251 (27%)
		Tryp_SPc	196..427	CDD:238113	68/253 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910