DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and prss12

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_002934300.3	Gene:	prss12 / 100495119	XenbaseID:	XB-GENE-984837	Length:	851	Species:	Xenopus tropicalis

Alignment Length:	351	Identity:	99/351 - (28%)
Similarity:	146/351 - (41%)	Gaps:	89/351 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LAECVR----LSSCQKDEKCTRLVSCSPLMNILRPRGMTQAEKDVFAHRQCGLDPNGHELLHMVY 81
            ||:|::    ..:|:..|...  |.|..::           :|..||..:        ||..:|
Frog   552 LADCIKQDIGTHNCRHSEDAG--VICDYII-----------KKSTFAANK--------ELSPLV- 594

  Fly    82 VCCPELGDVLPNKQTCGQTTPVFRDR---GAENAELNEYPWMVLLLY-----ENRL----SLIR- 133
                           ||......|.:   |.:|:....:||.|.|..     :.||    :||.
Frog   595 ---------------CGSRLQHRRPKRIIGGKNSVRGGWPWQVALRLKSSHGDGRLLCGATLISS 644

  Fly   134 -YVLTAAHCV--IGGYLTQNDLVLKSVRLGESTTDCITSESRCPHLDVEVGQTTVHQGFTSSGGT 195
             :|||||||.  .|     |:.....:|:|:..|  :..|..  ..|:.:.|..:|..:...|..
Frog   645 CWVLTAAHCFKRYG-----NNTRSYVIRVGDYHT--LVPEEY--EEDMTIQQIIIHNDYRPDGND 700

  Fly   196 YRNDIALLRL----QFPVRYTKKIQPICL-LDAEFPLQDL-NLQISGWDPT--KSSQTLITSTVK 252
            |  ||||:||    :..|:.:..:.|.|| |..|.|.:.. |..|:||..|  ..|:||..:||.
Frog   701 Y--DIALIRLHGTAEQCVQLSTHVLPACLPLRRERPQKTASNCYITGWGDTGRAYSRTLQQATVT 763

  Fly   253 ERNPADCLNRYPSFRSASQVCAGG---QRKGDTCAGISGSPVMGIMGSGVDEFVFLAGIASYGQQ 314
            ......|..||.|..:...:|||.   |:..|:|.|.||.|:: ...||....|:  |:.|:|
Frog   764 LLPKRVCEERYRSQFTGRMLCAGSVKTQKHVDSCQGDSGGPLV-CERSGGSWIVY--GVTSWG-- 823

  Fly   315 YCYSAGI---PGVYTKIGHFSEWIKA 337
              |..|:   ||||||:..|..|||:
Frog   824 --YGCGVKDSPGVYTKVSAFIPWIKS 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	8/48 (17%)
		Tryp_SPc	108..338	CDD:238113	83/257 (32%)
		Tryp_SPc	108..335	CDD:214473	80/253 (32%)
prss12	XP_002934300.3	KR	78..140	CDD:412161
		SRCR	148..244	CDD:395421
		SR	257..356	CDD:214555
		SR	363..461	CDD:214555
		SR	476..575	CDD:214555	6/24 (25%)
		Tryp_SPc	607..848	CDD:238113	83/259 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910