DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18754 and tmprss6

DIOPT Version :9

Sequence 1:	NP_652652.3	Gene:	CG18754 / 59145	FlyBaseID:	FBgn0042106	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	376	Identity:	98/376 - (26%)
Similarity:	132/376 - (35%)	Gaps:	100/376 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NQLAE----CVRLSSCQKDEKCTRLVS----------------CSPLMNILRPRGMTQAEKDVFA 63
            |:|.|    |.....|...|.|..:.|                |:...|.  |.....|.....|
Frog   471 NELDERNCVCPAQYHCPGAESCISITSVCDGKKDCANGTDEELCNQGANF--PTAACGAFNYKCA 533

  Fly    64 HRQCGLDPNGHELLHMVYVC-----CPELGDVLPNKQTCGQTTPVFRDRGAENAELNEYPWMVLL 123
            ...|...||..        |     ||:..|  .|...||......|..|...|:..|:||...|
Frog   534 DGSCVQKPNAE--------CDSIADCPDGSD--ENNCGCGIQAVGIRLVGGTQAQEGEWPWQASL 588

  Fly   124 ------LYENRLSLIRYVLTAAHCVI-GGYLTQN--DLVLKSVRLGESTTDCITSESRCPHLDVE 179
                  :....|...:::||||||.. ..|.:..  .:.|..|||..||.         ..|..:
Frog   589 QVRGEHICGGTLVADQWILTAAHCFTPESYASPEVWTVYLGKVRLSRSTQ---------KELAFK 644

  Fly   180 VGQTTVHQGFTSSGGTYRNDIALLRLQFPVRYTK-KIQPICLLDA--EFPLQDLNLQISGWDPTK 241
            |.:..:|..:......|  |:||:.|...|..|. .:|||||..:  .||... :..::||
Frog   645 VIRLVIHPFYDEDSHDY--DVALVLLDHLVPLTSPHVQPICLPSSTHHFPTGS-SCWVTGW---- 702

  Fly   242 SSQTLITSTVKERNPAD---------------CLNRYPSFRSASQVCAGGQRKG--DTCAGISGS 289
                   .:|||..|..               |...|....|...:|| |.|.|  |.|.|.|||
Frog   703 -------GSVKENGPTSDVLQKVDIQLVAQDICTELYRYQISPRMLCA-GYRDGSKDACQGDSGS 759

  Fly   290 PVMGIMGSGVDEFVFLAGIASYGQQYCYSAGIP---GVYTKIGHFSEWIKA 337
            |::....||   ..|.||:.|:|.    ..|||   |||::|....:||::
Frog   760 PLVCKTASG---RWFQAGLVSWGA----GCGIPRYFGVYSRITRLVQWIES 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18754	NP_652652.3	CLIP	35..84	CDD:288855	11/69 (16%)
		Tryp_SPc	108..338	CDD:238113	74/262 (28%)
		Tryp_SPc	108..335	CDD:214473	72/258 (28%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060	3/6 (50%)
		LDLa	480..514	CDD:238060	5/33 (15%)
		LDLa	525..560	CDD:238060	10/44 (23%)
		Tryp_SPc	572..804	CDD:238113	74/263 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910