DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18748 and CSR2

DIOPT Version :9

Sequence 1:	NP_001097703.1	Gene:	CG18748 / 59144	FlyBaseID:	FBgn0042105	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_015355.1	Gene:	CSR2 / 856142	SGDID:	S000006234	Length:	1121	Species:	Saccharomyces cerevisiae

Alignment Length:	475	Identity:	86/475 - (18%)
Similarity:	152/475 - (32%)	Gaps:	141/475 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 STDKAIQIKAIRLKLKGYAETHWTESKTDSNNKSTSESYNGFEKYLSSKVYLLGSEISPEMALEP 94
            |.:|:..:..|:::|.......|......:.|.: .|.||     :.|..:.|.::
Yeast   359 SLNKSTTLSDIKVELTSNVRVVWFNGLPPTKNVN-EECYN-----IGSLDWTLNAD--------- 408

  Fly    95 GTRSYNFACPIPINCPSSFEGTHGRIRYMVDVNIIQPWKYDSIFSRAFTVIQVM-DINTYNSVSQ 158
               ::|...|.....|......|...|.:..:..:...|..|..::|.....:: ::|..||.::
Yeast   409 ---NFNLFIPQGAKSPLDIVENHSNNRKLKVLQKLSMRKRRSFSNKAVLRENILNNLNASNSTNK 470

  Fly   159 VPVQAKTEKTFGVWPFRSDPLTLELNLPQTGFVPGQTV---------------------PANVLI 202
            :        ..||:.| :.|:.|...:|::.:.|...|                     |.:..|
Yeast   471 L--------NAGVYVF-TIPIVLASRIPESLYYPSARVSYSLRLATKLKDEHTQLVASRPRSSSI 526

  Fly   203 GNESKIRVHEVKVGLSMM--------ITYYSDLSSGSKCERKSVAKLKADGVLR--NSRKMYD-- 255
            .:..|:|.:.........        .||.:|.:|..|....|.....|.|.|:  ||....|
Yeast   527 SSPQKLRSYSCSDSYEYSQIDDTIEGETYNNDKNSTGKIAFPSSWLKSAKGRLKRNNSNGRSDNN 591

  Fly   256 --------------------FQLMIPSTPPSC--------FHLCRIIK--IGYQIEVVAKVKGMH 290
                                :.|.:..|||..        .::.::.:  :.|:|....|.  :.
Yeast   592 GASSSGLAMQHDSEDTINLQYPLNLVRTPPEISVTTANKPLYINKVWENCLSYEISFAQKY--VP 654

  Fly   291 INGTLIMPVTICGVPISPSAV------------------------QYTPQSSGPEAP-------- 323
            :||.:  |:||...|:..|..                        |..|.:|.|..|
Yeast   655 LNGEI--PITIKVAPLVKSLSVKRIRVSCREKISYRSKDYQYDFDQLDPLASDPCNPYHMRYLVR 717

  Fly   324 --EQRALTLIEGEGAFAPAAPPYPWSEGSTLSPPNYAEAMHSHSDSEKQ---SESGNAQEKSYKP 383
              :.|:|.|.  |.|....:.|....|..|.:..:...|..|..::.|.   |||...:.|...|
Yeast   718 KKKDRSLPLF--EVASKCTSGPSIREEVVTNTVDDNLLAYTSSKENNKDIPFSESFTVKTKLKFP 780

  Fly   384 LYPVFDLSTSTVEKSKEAAL 403
            .|       ..|:.:|.|:|
Yeast   781 KY-------CEVDATKAASL 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18748	NP_001097703.1	Arrestin_N	5..151	CDD:278754	19/121 (16%)
CG18748	NP_001097703.1	Arrestin_C	175..301	CDD:280848	31/188 (16%)
CSR2	NP_015355.1	Arrestin_C	638..>737	CDD:214976	20/104 (19%)
CSR2	NP_015355.1	Arrestin_C	<828..926	CDD:413500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930