DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18748 and ROD1

DIOPT Version :9

Sequence 1:	NP_001097703.1	Gene:	CG18748 / 59144	FlyBaseID:	FBgn0042105	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_014661.1	Gene:	ROD1 / 854183	SGDID:	S000005544	Length:	837	Species:	Saccharomyces cerevisiae

Alignment Length:	516	Identity:	102/516 - (19%)
Similarity:	182/516 - (35%)	Gaps:	148/516 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MVAGQVTLSTDKAIQIKAIRLKLKGYAE------------THWTESKTDSNNKS------TSESY 68
            :::|.:.||..:.||||::.|:|.|...            .|...||.:.|..|      ..:||
Yeast    40 LLSGTIVLSITEPIQIKSLALRLFGRLRLNIPTVLQTVHGPHKRYSKFERNIYSHFWDDFNIKSY 104

  Fly    69 --NGFEKYLSSKVYLLGSEISPEMALEP-----------------------------GTRSYNFA 102
              |.::.:.:.|: .:.|:.|..:|..|                             |...:.|:
Yeast   105 FQNLYDNHNNGKI-TISSKSSTNLAALPKRKRALSTASLISSNGQTSASKNYHTLVKGNYEFPFS 168

  Fly   103 CPIPINCPSSFEG-THGRIRYMVDVNIIQPWKYDSIFSRAFTVIQVMDINTYNSVSQVPVQAKTE 166
            ..||.:...|.|| .:..:.|.::..|.:|.:.|.|..:...||:.:.|:.......|.|.
Yeast   169 AIIPGSLVESVEGLPNAAVTYALEATIERPKQPDLICKKHLRVIRTLAIDAVELSETVSVD---- 229

  Fly   167 KTFGVWPFRSDPLTLELNLPQTGFVPGQTVPANVLIGNESK-IRVHEVKVGLSMMITYYSDLSSG 230
               ..||.:.|   ..:::|......|.:...|:||....| :::..|::.| :..:.|.....|
Yeast   230 ---NSWPEKVD---YTISIPTKAIAIGSSTMINILIVPILKGLKLGPVRISL-VENSQYCGSYGG 287

  Fly   231 SKCERKSVAKLKADGVLRNSRKMY------------------DFQ--------LMIPSTPPSCFH 269
            ...:.:.|||||....|::..::.                  :||        |.||::...|..
Yeast   288 VINQERMVAKLKLKDPLKHVAQIKKKRSLNEAADEGVDTDTGEFQDKWEVRALLNIPASLTKCSQ 352

  Fly   270 LCRI---IKIGYQIEVVAKVKGM--HING-TLIMPVTICGVPISP------SAVQYTPQSSGP-- 320
            .|||   ||:.::|:....:...  ||:. ...:||.:...|..|      ..::.|.::.||
Yeast   353 DCRILSNIKVRHKIKFTISLLNPDGHISELRAALPVQLFISPFVPVNVKTSDVIERTLKTFGPSY 417

  Fly   321 EAPEQRALTL--------IEGEGAFAPAAPPYPWS------EGSTLS------------------ 353
            :...|...:.        .|.:..|..:|.....|      .||||:
Yeast   418 QVTSQHDNSFSSKNFVDDSEEDVIFQRSASALQLSSMPTIVSGSTLNINSTDAEATAVADTTMVT 482

  Fly   354 ----PPNYAEAMH-------SHSDSEKQSESGNAQEKSYKPLYPVFDLSTSTVEKSKEAAL 403
                ||||...::       ::.|....|.|.:|.|.  :.::.:.:|..|....|....|
Yeast   483 SLMVPPNYGNHVYDRVYGEVTNEDETSASASSSAVES--QAIHNIQNLYISDSNNSNNPIL 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18748	NP_001097703.1	Arrestin_N	5..151	CDD:278754	37/178 (21%)
CG18748	NP_001097703.1	Arrestin_C	175..301	CDD:280848	33/158 (21%)
ROD1	NP_014661.1	Arrestin_N	<157..215	CDD:419887	14/57 (25%)
ROD1	NP_014661.1	Arrestin_C	232..395	CDD:214976	35/166 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343415
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840