DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18748 and ARRDC3

DIOPT Version :9

Sequence 1:	NP_001097703.1	Gene:	CG18748 / 59144	FlyBaseID:	FBgn0042105	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_065852.1	Gene:	ARRDC3 / 57561	HGNCID:	29263	Length:	414	Species:	Homo sapiens

Alignment Length:	386	Identity:	98/386 - (25%)
Similarity:	172/386 - (44%)	Gaps:	70/386 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VFYAGQMVAGQVTLSTDKAIQIKAIRLKLKGYAETHWTESKTDSNNKSTSESYNGFEKYLSSKVY 80
            |:.:|..|:|:|.|.....|::|::::..:|:|:..||||:...:|.:.:::|....:|.:.|..
Human    23 VYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDI 87

  Fly    81 LLGSEISPEMA------LEPGTRSYNFACPIPINCP--SSFEGTHGRIRYMVDVNIIQPWKYDSI 137
            |:|.|...:.:      :..|...|.|:..:| ..|  :||||.||.:||.|...:.:||.....
Human    88 LIGHERDDDNSEEGFHTIHSGRHEYAFSFELP-QTPLATSFEGRHGSVRYWVKAELHRPWLLPVK 151

  Fly   138 FSRAFTVIQVMDINTYNSVSQVPVQAKTEKTFGVWPFRSDPLTLELNLPQTGFVPGQTVPANVLI 202
            ..:.|||.:.:||||.:.:|  |.....|||...|...|.|::|...:.:.|:.||:::.....|
Human   152 LKKEFTVFEHIDINTPSLLS--PQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEI 214

  Fly   203 GNESKIRVHEVKVGLSMMITYYSDLSSGSKCERKS-VAKLKADGVLRNSRKMYDFQLM-IPSTPP 265
            .|.|. |:...|..:.....:|   :.|...|.|. ||.|:.:.:.....:.::.:|: ||...|
Human   215 ENCSS-RMVVPKAAIYQTQAFY---AKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSP 275

  Fly   266 SCFHLCRIIKIGYQIEVVAKVKG---MHINGTLIMPVTICGVPISPSAVQYTPQSSG-------- 319
            |... |.||::.|.:.|...:.|   :.:|    :|:.|..:|:.|...:.:..||.
Human   276 SILD-CSIIRVEYSLMVYVDIPGAMDLFLN----LPLVIGTIPLHPFGSRTSSVSSQCSMNMNWL 335

  Fly   320 ----PEAPEQRALTLIEGEGAFAPAAPPYPWSEGSTLSPPNYAEAMHSHSDSEKQSESGNA 376
                ||.||                            :||:|||.:     :|:|..:..|
Human   336 SLSLPERPE----------------------------APPSYAEVV-----TEEQRRNNLA 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18748	NP_001097703.1	Arrestin_N	5..151	CDD:278754	41/142 (29%)
CG18748	NP_001097703.1	Arrestin_C	175..301	CDD:280848	31/130 (24%)
ARRDC3	NP_065852.1	Arrestin_N	22..165	CDD:334019	41/142 (29%)
		Arrestin_C	187..314	CDD:214976	32/135 (24%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		2/2 (100%)
		PPxY motif 2. /evidence=ECO:0000305	391..394
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7402
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4428
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		mtm8525
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.870