DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18748 and ARRDC2

DIOPT Version :9

Sequence 1:	NP_001097703.1	Gene:	CG18748 / 59144	FlyBaseID:	FBgn0042105	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_056498.1	Gene:	ARRDC2 / 27106	HGNCID:	25225	Length:	407	Species:	Homo sapiens

Alignment Length:	394	Identity:	103/394 - (26%)
Similarity:	176/394 - (44%)	Gaps:	52/394 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VFYAGQMVAGQVTLSTDKAIQIKAIRLKLKGYAETHWTESKTDSNNKSTSESYNGFEKYLSSKVY 80
            ||..||.|||:|.|....|.::.|:||:.:|.|..|||||::..::.:.::||:...:.:|.:..
Human    23 VFSGGQAVAGRVLLELSSAARVGALRLRARGRAHVHWTESRSAGSSTAYTQSYSERVEVVSHRAT 87

  Fly    81 LLGSEISPEMALEPGTRSYNFACPIPINCPSSFEGTHGRIRYMVDVNIIQPWKYDSIFSRAFTVI 145
            ||..:......|.||...:.|:..:|....:||||.||.:||.:...:.:||.......:.||||
Human    88 LLAPDTGETTTLPPGRHEFLFSFQLPPTLVTSFEGKHGSVRYCIKATLHRPWVPARRARKVFTVI 152

  Fly   146 QVMDINTYNSVSQVPVQAKTEKTFGVWPFRSDPLTLELNLPQTGFVPGQTVPANVLIGNESKIRV 210
            :.:||||  .....|.....||....|......::|...:.:.|:.||:.:|....|.|.|...|
Human   153 EPVDINT--PALLAPQAGAREKVARSWYCNRGLVSLSAKIDRKGYTPGEVIPVFAEIDNGSTRPV 215

  Fly   211 HEVKVGLSMMITYYSDLSSGSKCERKS-VAKLKADGVLRNSRKMYDFQ-LMIPSTPPSCFHLCRI 273
                :..:.::...:.::.|::.:::: ||.|..:.|....|.::..: |.||...||..| ||:
Human   216 ----LPRAAVVQTQTFMARGARKQKRAVVASLAGEPVGPGQRALWQGRALRIPPVGPSILH-CRV 275

  Fly   274 IKIGYQIEVVAKVKGMHINGTLIMPVTICGVPISPSAVQYTPQSSG------------------- 319
            :.:.|.::|...:.|.. ...|.:|:.|..:|:.|    :..:||.
Human   276 LHVDYALKVCVDIPGTS-KLLLELPLVIGTIPLHP----FGSRSSSVGSHASFLLDWRLGALPER 335

  Fly   320 PEAPEQRALTLIEGEGAFAPAAP-PYPWSEGSTLSPPNYAEAMHSHSDSEKQSESGNAQEKSYK- 382
            ||||.:.:..:.:.|.|....:| |.|.....:|..|.:|                ..||..|:
Human   336 PEAPPEYSEVVADTEEAALGQSPFPLPQDPDMSLEGPFFA----------------YIQEFRYRP 384

  Fly   383 -PLY 385
             |||
Human   385 PPLY 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18748	NP_001097703.1	Arrestin_N	5..151	CDD:278754	45/134 (34%)
CG18748	NP_001097703.1	Arrestin_C	175..301	CDD:280848	28/127 (22%)
ARRDC2	NP_056498.1	Arrestin_N	9..158	CDD:278754	45/134 (34%)
ARRDC2	NP_056498.1	Arrestin_C	181..307	CDD:214976	29/131 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7402
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4428
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		mtm8525
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870