DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18748 and arrd-25

DIOPT Version :9

Sequence 1:	NP_001097703.1	Gene:	CG18748 / 59144	FlyBaseID:	FBgn0042105	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_510338.1	Gene:	arrd-25 / 181514	WormBaseID:	WBGene00007296	Length:	584	Species:	Caenorhabditis elegans

Alignment Length:	516	Identity:	106/516 - (20%)
Similarity:	177/516 - (34%)	Gaps:	174/516 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FYAGQMVAGQVTLSTDKAIQIKAIRLKLKGYAETHWTE---SKTDSNNKSTSESYNGFEKYLSSK 78
            |..|:::.|::.:...|.|.|.|::|::||.|.  |..   .|.|.......:.:...|:
Worm    23 FKGGELITGKLLIELRKPIIINAVKLQMKGRAA--WLNDPLKKDDIEKVYFDQDFTLLER----- 80

  Fly    79 VYLLGSEISPEMALEPG--------TRSYNFACPIPINCPSSFEGTHGRIRYMVDVNIIQPWKYD 135
                     |....|||        |.|..|.||:|..|||::||.|..|||.:..:::|..:::
Worm    81 ---------PPGKPEPGHFQWIGDFTYSLPFECPLPKGCPSTYEGPHAFIRYFIRASLVQEDEFE 136

  Fly   136 SI----FSRAFTVIQVMDINTYNSVSQVPVQAKTEKTFGVWPFRSDPLTLELNLPQTGFVPGQTV 196
            .|    ..:|||::...:   .:.|:....|.......|....:| .|..||.|.:||::||:.:
Worm   137 KIHEYYVKKAFTLVSPSE---GHIVTGEAAQTDDSAILGKCCCKS-KLAAELALSKTGYLPGEAI 197

  Fly   197 PANVLIGN----------ESKIRVHEVKVGLSMMITYYSDLSSGS--------KCERKSVAKLKA 243
            ..|:.||:          |:::.....:||.       .::|:.|        |.|.......|.
Worm   198 YGNLKIGSKHPKDILNHMEARLVDRVRRVGA-------PEISAASPWRTLLVRKLESNQETPAKT 255

  Fly   244 DGVLRNSRKMYDFQLMIPSTPPSC---------------------------------FHLCRIIK 275
            .|.:..|      .|.:.:.||.|                                 |.....:|
Worm   256 KGAIEQS------GLFLLTVPPVCPSTKGDYEDPSKIEHILSPYGKLLESPSTATLRFRKIPFLK 314

  Fly   276 IGYQIEVVAKVKGMHINGTLIMPVTICGVPISPSAVQYTPQS-------SGP---EAPEQRALTL 330
            :.|.|:|..        ||.|    :..:||....:....:|       :||   |..:::....
Worm   315 VEYGIQVTL--------GTDI----LLEIPIEIGELSTRDKSNTLESFVTGPQPVEEADEKGKIA 367

  Fly   331 IEGEGAFAPAAPPYPWSEGST---------LSPPNYAEAMH--------------SHSDSEKQSE 372
            :.|...:.|.. |||.:.|:.         .:.|:...:|:              :|||..   |
Worm   368 VNGPFVYTPVY-PYPQNAGTNGKAASVTVISTEPSLPHSMYEPEKTIVTTTRTIVTHSDGH---E 428

  Fly   373 SGNAQE-----------------------KSYKPLYPVFDLS---TSTVEKSKEAALDKEE 407
            |...:|                       |:.|......|.|   .:|||.||....:..|
Worm   429 SKTMEETVVETEGEVVKTVLESTVNDDGMKTEKVETTTIDASGDEKTTVETSKTRVAESAE 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18748	NP_001097703.1	Arrestin_N	5..151	CDD:278754	39/148 (26%)
CG18748	NP_001097703.1	Arrestin_C	175..301	CDD:280848	34/176 (19%)
arrd-25	NP_510338.1	Arrestin_N	11..152	CDD:389964	39/144 (27%)
arrd-25	NP_510338.1	Arrestin_C	179..336	CDD:214976	35/181 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920