Protein Alignment CG18746 and ARRDC1

DIOPT Version :10

• Sequence 1: NP_652649.1
• Gene: CG18746 / 59142
• FlyBaseID: FBgn0042103
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: XP_006717383.1
• Gene: ARRDC1 / 92714
• HGNCID: 28633
• Length: 466
• Species: Homo sapiens
• Alignment Length: 356
• Identity: 84/356 - (23%)
• Similarity: 136/356 - (38%)
• Gaps: 79/356 - (22%)

  Fly    73 YLATRAYLHGSSSSIEV-LIEPGTSSYRFACQLPITCPSSFEGTLGRIRYLVNV-----RFVRPW 131
            ::....|.:.|.|..:. .:..|..|:.|...||.|.|:||||..|:|.:.|..     ||.:..
Human    67 WVVEEGYFNSSLSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRAAIHTPRFSKDH 131

  Fly   132 KFDLNFNRCFTVIKVMDLNS----ESLMLRVPSQ------------VESQRTFCCFPCRSSPLSM 180
            |..|    .|.::..::|||    |...||.|::            ..:.:.|.....::..:.:
Human   132 KCSL----VFYILSPLNLNSIPDIEGSSLRTPAKPLPGPPPKQPNVASATKKFSYKLVKTGSVVL 192

  Fly   181 RLSVPQSGFVPGQIVPVEVMVSNDSGVAVEDITVKLTMVVIYYSQPPSADTNKDRFEMVLKT--- 242
            ..|....|:|.||.:.:...|.|.||.....:...|...|.|.::         |:...::|
Human   193 TASTDLRGYVVGQALQLHADVENQSGKDTSPVVASLLQKVSYKAK---------RWIHDVRTIAE 248

  Fly   243 --GGGVSTKCRQQFTFDLKVPPTPPTCFNLCSIIQIGYQVEAEARVKGCHGGQSLHMPITIGSVP 305
              |.||....|.|:...:.||..|.:....||:|.|.|.::...:....    ::.:|:.||::.
Human   249 VEGAGVKAWRRAQWHEQILVPALPQSALPGCSLIHIDYYLQVSLKAPEA----TVTLPVFIGNIA 309

  Fly   306 LTKQLQKEPRTWGEVLPPQQLDAKALILIGSEQNGEALGSPNPWAADPSIAPPSYAEAKHISPDP 370
            : ......||. |..|||                    |:| |... ||..|...|||:..:..|
Human   310 V-NHAPVSPRP-GLGLPP--------------------GAP-PLVV-PSAPPQEEAEAEAAAGGP 350

  Fly   371 H----KFSKSKKKSQKR-------GVKGSQE 390
            |    .|..:|..||::       .|.|:.|
Human   351 HFLDPVFLSTKSHSQRQPLLATLSSVPGAPE 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18746	NP_652649.1	Arrestin_N	4..150	CDD:425619	22/82 (27%)
		Arrestin_C	174..306	CDD:214976	30/136 (22%)
ARRDC1	XP_006717383.1	Arrestin_N	<82..146	CDD:451447	19/67 (28%)
		Arrestin_C	186..308	CDD:460676	30/134 (22%)