DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18746 and Arrdc4

DIOPT Version :9

Sequence 1:	NP_652649.1	Gene:	CG18746 / 59142	FlyBaseID:	FBgn0042103	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001036057.1	Gene:	Arrdc4 / 66412	MGIID:	1913662	Length:	415	Species:	Mus musculus

Alignment Length:	376	Identity:	85/376 - (22%)
Similarity:	159/376 - (42%)	Gaps:	42/376 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FCNNSQGIFYAGQLISGQVVIKTEKEKSVKAVILNIKGYAETHWADTEHDPDDQSNGE-SFNGHV 71
            |.:.|:|.:.:|:.::|.|:::..:..:::.:.|..:|.|.:.|..:.........|. :.:..|
Mouse    21 FEDESKGCYSSGETVAGHVLLEAAEPVALRGLRLEAQGRATSAWGPSAGARVCIGGGSPAASSEV 85

  Fly    72 DYLATR-AYLHGSSSSIEVLIEPGTSSYRFACQLPI-TCPSSFEGTLGRIRYLVNVRFVRPWKFD 134
            :||..| :.|...:.....|::||...:.|..|||. ...:||.|..|.|:|.|.....||...|
Mouse    86 EYLNLRLSLLEAPAGEGVTLLQPGKHEFPFRFQLPSEPLATSFTGKYGSIQYCVRAVLERPQVPD 150

  Fly   135 LNFNRCFTVIKVMDLNSESLMLRVPSQVESQRTFCCFPCRSSPLSMRLSVPQSGFVPGQIVPVEV 199
            .:..|...|:..:|:|:..|:  .|.....::...|:...|.|:|:.:.:.:.|:..|:.:|:..
Mouse   151 QSVRRELQVVSHVDVNTPPLL--TPMLKTQEKMVGCWLFTSGPVSLSVKIERKGYCNGEAIPIYA 213

  Fly   200 MVSNDSGVAVEDITVKLTMVVIYYSQP--PSADTNKDRFEMVLKTGGGVSTKCRQQFTFD-LKVP 261
            .:.|.|...|      :....|:.:|.  .|..|...|..:....|..:.:.....:... ||:|
Mouse   214 EIENCSSRLV------VPKAAIFQTQTYLASGKTKTVRHMVANVRGNHIGSGSTDTWNGKMLKIP 272

  Fly   262 PTPPTCFNLCSIIQIGYQVEAEARVKGCHGGQSLHMPITIGSVPLTKQLQKEPRTWGEVLPPQQL 326
            |..|:..: |.||::.|.:.....:.|.. ...|.:|:.||::|.:...::.    ..|.....:
Mouse   273 PVTPSILD-CCIIRVDYSLAVYIHIPGAK-RLMLELPLVIGTIPYSGFGRRN----SSVASQFSM 331

  Fly   327 DAKALILIGSEQNGEALGSPNPWAADPSIAPPSYAE-------AKHISPDP 370
            |...|.|...||              |. |||:||:       ::|:.|.|
Mouse   332 DMCWLALALPEQ--------------PE-APPNYADVVSEEEFSRHVPPYP 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18746	NP_652649.1	Arrestin_N	4..150	CDD:278754	36/144 (25%)
CG18746	NP_652649.1	Arrestin_C	174..306	CDD:214976	29/134 (22%)
Arrdc4	NP_001036057.1	Arrestin_N	19..166	CDD:306778	36/144 (25%)
		Arrestin_C	188..315	CDD:214976	29/134 (22%)
		PPxY motif 1. /evidence=ECO:0000305	347..350		2/2 (100%)
		PPxY motif 2. /evidence=ECO:0000305	392..395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10262
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	145	1.000	Inparanoid score	I4409
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm42766
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.870