DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18746 and CG2993

DIOPT Version :9

Sequence 1:	NP_652649.1	Gene:	CG18746 / 59142	FlyBaseID:	FBgn0042103	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001262348.1	Gene:	CG2993 / 40924	FlyBaseID:	FBgn0037521	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	128/529 - (24%)
Similarity:	213/529 - (40%)	Gaps:	114/529 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CEIEFCNNSQGIFYAGQLISGQVVIKTEKEKSVKAVILNIKGYAETHWADTEHDPDDQSNGESFN 68
            |.|.|.||.||::||||.:||.|.:..:..|.:|.:.:.:.|||:..|....:..|  |......
  Fly     5 CLISFDNNPQGVYYAGQELSGVVDLSVDATKRIKGIHVTVSGYAKIRWIKKGYPRD--SERAMCR 67

  Fly    69 GHVDYLATRAYLHGSSSSIEVLIEP-GTSSYRFACQLPITCPSSFEGTLGRIRYLVNVRFVRPWK 132
            .:..||::|:|:.||.::...:..| |..||.|...||...|:||:|..|:|.|.:.....|..:
  Fly    68 AYRSYLSSRSYVLGSCANNSSIDWPAGEYSYTFHVILPDNLPTSFDGKYGQIHYEIITTIERAAR 132

  Fly   133 FDLNFNRCFTVIKVMDLNSESLMLRVPSQVESQRTFCCFPCRSSPLSMRLSVPQSGFVPGQIVPV 197
            ....|...||||:.:|||:::: .|||.::..::.|..|.|.:.||:::.|.|..|:.|||.:..
  Fly   133 HPKVFKLPFTVIQPLDLNADAI-YRVPLEILDRKRFWSFCCPTGPLTVKFSTPYCGYAPGQKIHF 196

  Fly   198 EVMVSNDSGVAVEDITVKLTMVVIYYSQPPSADTNKDRFEMVLKTGGGVSTKCRQQFTFDLKVPP 262
            .:.::|:|.:.:.:..|||...|.|.|..|..:...|:..:..|..|.|....|:.:...|.:|.
  Fly   197 VLYINNESSIDIIECEVKLKQEVSYESHDPQHEYRYDKHLIARKQFGNVLRWSRKVYRGYLDLPS 261

  Fly   263 TPPTCFNLCSIIQIGYQVEAEARVKGCHGGQSLHMPITIGSVPL--------------------- 306
            .|||.......|.:.|.::........|....|.:|:||||:|:
  Fly   262 IPPTSVKPTCPISVNYSIKIIVNPTEFHWKLKLKIPLTIGSIPIMDGPEALLRFNRQQQQHQVVS 326

  Fly   307 ------TKQLQKEPRTWGEVLPPQQLD-------------AKALILIGSEQN--GEALG------ 344
                  |:|.|::.....::...::.|             .:.:..|.:..|  |..:|
  Fly   327 QNLQMSTQQRQRDRDRDRDMNVDRERDRDRDRDRISASVQQRRISSINNNNNNHGRLVGGLLPTN 391

  Fly   345 ---------SPNPWAADPS------------------------------IAPPSYAEAKHISPDP 370
                     ||.|.::.||                              :.||||.:|..:|
  Fly   392 SNMNMITNVSPTPTSSTPSSTPTTAALRPTAMPAILVTSDSDNPPDYIPMMPPSYEDAMALS--- 453

  Fly   371 HKFSKSKK---KSQKRGVKGSQERKAETIVFSPLYAV--------------FDLSNQVDEMTLRA 418
            .|||...:   ......:..:|.....:..|.|.|.|              :|.|:....:||..
  Fly   454 EKFSDDTEFLTNVSMSSILSAQADVTTSEPFKPRYPVYYDYETPTIPPETLYDESSSRLRLTLSC 518

  Fly   419 NE---PKTD 424
            .:   |:||
  Fly   519 QDSAAPETD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18746	NP_652649.1	Arrestin_N	4..150	CDD:278754	49/146 (34%)
CG18746	NP_652649.1	Arrestin_C	174..306	CDD:214976	36/131 (27%)
CG2993	NP_001262348.1	Arrestin_N	5..150	CDD:304627	49/146 (34%)
CG2993	NP_001262348.1	Arrestin_C	173..302	CDD:280848	34/128 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464072
Domainoid	1	1.000	62	1.000	Domainoid score	I10262
eggNOG	1	0.900	-	-		E1_KOG3780
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	43	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110793at6960
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm24709
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
	10	9.900