DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18746 and arrd-22

DIOPT Version :9

Sequence 1:	NP_652649.1	Gene:	CG18746 / 59142	FlyBaseID:	FBgn0042103	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_503955.1	Gene:	arrd-22 / 188642	WormBaseID:	WBGene00020612	Length:	456	Species:	Caenorhabditis elegans

Alignment Length:	462	Identity:	115/462 - (24%)
Similarity:	181/462 - (39%)	Gaps:	105/462 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IFYAGQLISGQVVIKTEKEKSVKAVILNIKGYAETHWADTEHDPDDQSNGESFNGHVDYLATRAY 79
            :|..||.|||:||:.|:|:.|.:||.:.|.|.|.|.|.:.|:     |...||:..|.|.....|
Worm    17 VFLPGQPISGRVVLTTKKKLSARAVNIKIVGLAHTSWKNYEN-----SCKLSFHRIVSYRPHGVY 76

  Fly    80 LHGSSSSIEVL---------------IEPGTSSYRFACQLPITCPSSFEGTLGRIRYLVNVRFVR 129
            .   |::::.|               :..|..::.|:..||:..|.||||..|.:||.|.|...|
Worm    77 Y---SANVKYLDYTQLLWTCGEGPKELNAGEYAWPFSYTLPLNIPPSFEGKYGYLRYTVKVEVDR 138

  Fly   130 PWKFDLNFNRCFTVIKVMDLN--SESLMLRVPSQVESQRTFCCFPCRSSPLSMRLSVPQSGFVPG 192
            ||:.|.....|.||..::|||  ..|| ..:.:|.......|||  ::..|.|.:::|::|||||
Worm   139 PWRVDKAKKMCITVSPLLDLNVIPHSL-TPINTQASENLGCCCF--KNGFLEMNVNIPKTGFVPG 200

  Fly   193 QIVPVEVMVSNDSGVAVEDITVKLTMVVIYYSQPPSADTN----------------------KDR 235
            :.||:.:.:.|.|....:.|..|:.....:......|..|                      ::.
Worm   201 ETVPLNIHLINHSSSTAKKIEAKILQQCKFTGYKDGATYNYGGDENMSEKAQRIMFDTKTVVRES 265

  Fly   236 FEMVLKTGGGVSTKCRQQFTFDLKVPPTPPTCFNLCSIIQIGYQVEAEARVKG-CHGGQSLHMPI 299
            .::|      |:.|...:|..:|::|...||......::.:.|.::.:..... .|........|
Worm   266 QKLV------VAAKNEHKFVLELRIPSVTPTINQFSPVVTVEYLIQLKVDTSAMSHSEVRCETSI 324

  Fly   300 TIGSVPLTK------------QLQKEPRTWGE-VLPP-----------QQLDAKALILIGSEQNG 340
            .:||||:.:            .|..:|...|| |.||           .:....|...:|...|.
Worm   325 LLGSVPIRQCLPPSYYQQDPSVLPSKPTPIGEGVAPPPGYGSLPMTDDSEKGTDAPYPLGLYPNV 389

  Fly   341 EALGSPNPW------AADPSIAPPSYAEAKHISPDPHKFSKSKKKSQKRGVKGSQERKAETIVFS 399
            ..:..|.|.      |..||..||||.|:.:                  |..|:.....|...:.
Worm   390 NDVNLPYPSVVQDGNAVIPSAPPPSYQESMY------------------GKGGTVLDAKENEPYV 436

  Fly   400 PLYAVFD 406
            |.|.||:
Worm   437 PKYPVFN 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18746	NP_652649.1	Arrestin_N	4..150	CDD:278754	49/149 (33%)
CG18746	NP_652649.1	Arrestin_C	174..306	CDD:214976	30/154 (19%)
arrd-22	NP_503955.1	Arrestin_N	7..159	CDD:334019	49/149 (33%)
arrd-22	NP_503955.1	Arrestin_C	182..330	CDD:214976	29/153 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I4648
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H119234
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46400
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm14113
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.930