DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18746 and arrd-11

DIOPT Version :9

Sequence 1:	NP_652649.1	Gene:	CG18746 / 59142	FlyBaseID:	FBgn0042103	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_496883.2	Gene:	arrd-11 / 187635	WormBaseID:	WBGene00011052	Length:	423	Species:	Caenorhabditis elegans

Alignment Length:	426	Identity:	119/426 - (27%)
Similarity:	181/426 - (42%)	Gaps:	65/426 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IFYAGQLISGQVVIKTEKEK-SVKAVILNIKGYAETHWAD------TEHDPDDQSNGES--FNGH 70
            :|:.||.|||:||:.|.:|| ..:||.:.|.|.|.|.|.|      .::|.:.:.:.||  ::.:
Worm    16 VFFPGQPISGRVVLSTTEEKYKARAVNIKILGLAHTSWTDYDSVRRVDNDGNVRYDSESVHYSSN 80

  Fly    71 VDYLATRAYL----HGSSSSIEVLIEPGTSSYRFACQLPITCPSSFEGTLGRIRYLVNVRFVRPW 131
            |.||.....|    .||:.     :..|...:.|:..||:..|.||||..|.:||.|.....|||
Worm    81 VHYLDQALLLWACKDGSNE-----LSAGDYVWPFSYTLPLNVPPSFEGKYGYLRYSVTAEVDRPW 140

  Fly   132 KFDLNFNRCFTVIKVMDLNSESLMLRVPSQVESQRTFCCFPCRSSPLSMRLSVPQSGFVPGQIVP 196
            :.|....||.||..::|||:..|.|......||:...||| .|...|.:|:::|::|||||:.||
Worm   141 RLDKAKRRCITVSPLIDLNAIPLALTPIDDEESENLGCCF-FRKGYLELRVNIPKTGFVPGETVP 204

  Fly   197 VEVMVSNDSGVAVEDITVKLTMVVIYYSQPPSADTNKDRFEMVLKTGGGVSTKC----------- 250
            :.:.:.|.|.|.|.::..|:.....:.:.........|.....|.:|....||.
Worm   205 MNIHILNHSSVPVTEVKAKIIQQCKFIAYRNGTIFRFDGGSDTLMSGSSQQTKYDTKPVITQTQP 269

  Fly   251 -------RQQFTFDLKVPPTPPTCFNLCSIIQIGYQVEAEARVKG-CHGGQSLHMPITIGSVPLT 307
                   ..:|..:.::|...||......:|.:.|.|:....... |.......|||.||:||:.
Worm   270 MTVTPGNEHKFVLEFRLPSVTPTICRFSPVITVEYVVQVRVETTSTCGSAAKCEMPILIGTVPIR 334

  Fly   308 KQLQKE-PRTWGEVLPPQQLDAKALILIGSEQNGEALGSPNPWAADPSIAPPSYAEAKHISPDPH 371
            ..|... |..:...|||...:.       ::.|.......:..|..||..||||.|:.:
Worm   335 NYLPPPIPNNYPIGLPPPYANL-------TDVNVPCPSGGSGTAVIPSAPPPSYQESMY------ 386

  Fly   372 KFSKSKKKSQKRGVKGSQERKAET-IVFSPLYAVFD 406
                        ||.|::.|..|. ..|:|.|.||:
Worm   387 ------------GVGGTELRAEENEKPFAPKYPVFN 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18746	NP_652649.1	Arrestin_N	4..150	CDD:278754	50/147 (34%)
CG18746	NP_652649.1	Arrestin_C	174..306	CDD:214976	35/150 (23%)
arrd-11	NP_496883.2	Arrestin_N	6..159	CDD:334019	50/147 (34%)
arrd-11	NP_496883.2	Arrestin_C	182..332	CDD:214976	34/149 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I4648
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H119234
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46400
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		mtm4733
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.930