DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18744 and ARRDC4

DIOPT Version :9

Sequence 1:	NP_652647.2	Gene:	CG18744 / 59140	FlyBaseID:	FBgn0042101	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_899232.2	Gene:	ARRDC4 / 91947	HGNCID:	28087	Length:	418	Species:	Homo sapiens

Alignment Length:	440	Identity:	95/440 - (21%)
Similarity:	168/440 - (38%)	Gaps:	139/440 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DNPRGVYRAGDTVNGHVYLTLSERALIKAICLEANGYASTAWQQPQKHKNQKKNEQPVVVQSLDF 74
            |..:|.|.:|:||.|||.|..||...::|:.|||.|.|:.|| .|........:...:.|
Human    26 DERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAW-GPSTCPRASASTAALAV----- 84

  Fly    75 DYRVDYFAKIDYF-VGSEAAQPQ------IMEAGTYNYGFHVKLPKN-CPGNFEGGHGHIRYTLQ 131
                  |::::|. |.....:|.      :::.|.:.:.|..:||.. ...:|.|.:|.|:|.::
Human    85 ------FSEVEYLNVRLSLREPPAGEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVR 143

  Fly   132 VLIHSSADRPLEVLHVRQLQIFPQNSLSQETRSCEIQIYEQ---------TPRLR---------- 177
            .::    :||.          .|..|:.:     |:|:...         ||.|:
Human   144 AVL----ERPK----------VPDQSVKR-----ELQVVSHVDVNTPALLTPVLKTQEKMVGCWF 189

  Fly   178 FWMKPLHLQLQIPRQGYSPGAGISVHLKLHN-PEKLTLREAVYSLVQISTYVAHLKNKPKRLETK 241
            |...|:.|..:|.|:||..|..|.::.::.| ..:|.:.:|  ::.|..||:|..|.|
Human   190 FTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLIVPKA--AIFQTQTYLASGKTK------- 245

  Fly   242 VERQTVLSSRHELHNLPRGELQNFQHL----------HMLQVPQTAATLTVAGCACLQLNYEVEV 296
                   :.||.:.|: ||     .|:          ..|::|  ..|.::..|..::::|.:.|
Human   246 -------TIRHMVANV-RG-----NHIASGSTDTWNGKTLKIP--PVTPSILDCCIIRVDYSLAV 295

  Fly   297 LVTTQQEKRLIAARMPVIIGNVTPPCPGKLLMQEPIDGTAPEPTPPVETASTLIPNFSISTTSLA 361
            .:.....|:|: ..:|::||.:            |.:|                  |....:|:|
Human   296 YIHIPGAKKLM-LELPLVIGTI------------PYNG------------------FGSRNSSIA 329

  Fly   362 SNF-REAEFMVATNLNKTNKHYLSGEQLDFRPRYVYYEMDQTQSEEVKSH 410
            |.| .:..::..|          ..||.:..|.|.    |....||...|
Human   330 SQFSMDMSWLTLT----------LPEQPEAPPNYA----DVVSEEEFSRH 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18744	NP_652647.2	Arrestin_N	5..141	CDD:304627	35/138 (25%)
CG18744	NP_652647.2	Arrestin_C	179..322	CDD:214976	34/153 (22%)
ARRDC4	NP_899232.2	Arrestin_N	26..169	CDD:278754	41/173 (24%)
		Arrestin_C	191..318	CDD:214976	34/163 (21%)
		PPxY motif 1. /evidence=ECO:0000305	350..353		1/2 (50%)
		PPxY motif 2. /evidence=ECO:0000305	395..398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820