DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG18744 and ARRDC3

DIOPT Version :9

Sequence 1:NP_652647.2 Gene:CG18744 / 59140 FlyBaseID:FBgn0042101 Length:410 Species:Drosophila melanogaster
Sequence 2:NP_065852.1 Gene:ARRDC3 / 57561 HGNCID:29263 Length:414 Species:Homo sapiens


Alignment Length:433 Identity:96/433 - (22%)
Similarity:168/433 - (38%) Gaps:104/433 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 VYRAGDTVNGHVYLTLSERALIKAICLEANGYASTAWQQPQKHKNQKKNEQPVVVQSLDFDYRVD 79
            ||.:||||:|.|.|.::....:|::.:.|.|:|...|       .:.:|.......:.::...|:
Human    23 VYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRW-------TESRNAGSNTAYTQNYTEEVE 80

  Fly    80 YFAKIDYFVGSEAAQPQIME------AGTYNYGFHVKLPKN-CPGNFEGGHGHIRYTLQVLIHSS 137
            ||...|..:|.|.......|      :|.:.|.|..:||:. ...:|||.||.:||.::..:|  
Human    81 YFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELH-- 143

  Fly   138 ADRP--LEVLHVRQLQIF------------PQNSLSQETRSCEIQIYEQTPRLRFWM---KPLHL 185
              ||  |.|...::..:|            ||....::|..|             |.   .|:.|
Human   144 --RPWLLPVKLKKEFTVFEHIDIN
TPSLLSPQAGTKEKTLCC-------------WFCTSGPISL 193

  Fly   186 QLQIPRQGYSPGAGISVHLKLHN--PEKLTLREAVYSLVQISTYVAHLKNKPKRLETKVERQTVL 248
            ..:|.|:||:||..|.:..::.|  ...:..:.|:|     .|...:.|.|.|.:     :|.|.
Human   194 SAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIY-----QTQAFYAKGKMKEV-----KQLVA 248

  Fly   249 SSRHELHNLPRGELQNFQHLHMLQVPQTAATLTVAGCACLQLNYEVEVLVTTQQEKRLIAARMPV 313
            :.|.|  :|..|:.:.:.. .:|::|..:.  ::..|:.:::.|.:.|.|.......|. ..:|:
Human   249 NLRGE--SLSSGKTETWNG-KLLKIPPVSP--SILDCSIIRVEYSLMVYVDIPGAMDLF-LNLPL 307

  Fly   314 IIG------------NVTPPCP---GKLLMQEPIDGTAPEPTPPVETASTLIPNFSISTTSLASN 363
            :||            :|:..|.   ..|.:..|....||.....|.|......|  ::..|...:
Human   308 VIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNN--LAPVSACDD 370

  Fly   364 FREAEFMVATNLNKTNKHYLSG------EQLDFRPRYVYYEMD 400
            |..|               |.|      ::..|.|..:|.|:|
Human   371 FERA---------------LQGPLFAYIQEFRFLPPPLYSEID 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18744NP_652647.2 Arrestin_N 5..141 CDD:304627 35/132 (27%)
Arrestin_C 179..322 CDD:214976 34/159 (21%)
ARRDC3NP_065852.1 Arrestin_N 22..165 CDD:334019 40/152 (26%)
Arrestin_C 187..314 CDD:214976 32/142 (23%)
PPxY motif 1. /evidence=ECO:0000305 346..349 1/2 (50%)
PPxY motif 2. /evidence=ECO:0000305 391..394 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..414 3/6 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3780
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D311636at33208
OrthoFinder 1 1.000 - - FOG0000089
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X122
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

Return to query results.
Submit another query.