DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and Prss12

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_445956.1	Gene:	Prss12 / 85266	RGDID:	69238	Length:	761	Species:	Rattus norvegicus

Alignment Length:	283	Identity:	92/283 - (32%)
Similarity:	128/283 - (45%)	Gaps:	45/283 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SSPAKRECAECSCGNINTRH----RIVGGQETEVHEYPWMIMLM-----WFGNFYCGASLVNDQY 117
            |....:|.....|| :...|    ||:||..:....:||...|.     ..|...|||:|::..:
  Rat   493 SGHGNKETLSSGCG-LRLLHRRQTRIIGGNNSLRGAWPWQASLRLKSTHGDGRLLCGATLLSSCW 556

  Fly   118 ALTAAHCVN-------------GFYHRLITVRLLEHNRQDSHVKIVDRRVSRVLIHPKYSTRNFD 169
            .||||||..             |.||.|:.    |...||..|:       :::||..|...:.|
  Rat   557 VLTAAHCFTRYGNNSRSYAVRVGDYHTLVP----EGFEQDIGVQ-------QIVIHRNYRPDSSD 610

  Fly   170 SDIALIRF----NEPVRLGIDMHPVCMPTPSE--NYAGQTAVVTGWGALSEGGPISDTLQEVEVP 228
            .||||:|.    .:..||...:.|.|:|...|  ........:||||  ..|...|.|||:..||
  Rat   611 YDIALVRLQGSGEQCARLSTHVLPACLPLWRERPQKTASNCHITGWG--DTGRAYSRTLQQAAVP 673

  Fly   229 ILSQEECRNSNYGESKITDNMICAGYVEQGGK-DSCQGDSGGPMHVLGSGDAYQLAGIVSWGEGC 292
            :|.:..|:....|  ..|..|:|||.:::..: ||||||||||:......:.:.:.|:.|||.||
  Rat   674 LLPKRFCKERYKG--LFTGRMLCAGNLQEDNRVDSCQGDSGGPLMCEKPDETWVVYGVTSWGYGC 736

  Fly   293 AKPNAPGVYTRVGSFNDWIAENT 315
            ...:.|||||||.:|..||...|
  Rat   737 GIKDTPGVYTRVPAFVPWIKSVT 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	84/253 (33%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	85/255 (33%)
Prss12	NP_445956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..89
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..266	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555
		SRCR	391..485	CDD:278931
		Zymogen activation region. /evidence=ECO:0000250	505..516		3/11 (27%)
		Tryp_SPc	516..755	CDD:214473	84/253 (33%)
		Tryp_SPc	517..758	CDD:238113	85/255 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910