DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and TMPRSS13

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_001070731.1	Gene:	TMPRSS13 / 84000	HGNCID:	29808	Length:	567	Species:	Homo sapiens

Alignment Length:	285	Identity:	94/285 - (32%)
Similarity:	154/285 - (54%)	Gaps:	22/285 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NNLAQLRQSSFLDWIQSILGPEVPAEWSSPAKRECAECS-CGNINTRHRIVGGQETEVHEYPWMI 98
            |:.:.||.:|.:.  :|:...|.|::     :....:|| ||......|||||......::||.:
Human   284 NSFSILRYNSTIQ--ESLHRSECPSQ-----RYISLQCSHCGLRAMTGRIVGGALASDSKWPWQV 341

  Fly    99 MLMWFGNFYCGASLVNDQYALTAAHCVNGFYHRLITVRLLE-----HNRQDSHVKIVDRRVSRVL 158
            .|.:.....||.:|::.|:.||||||   |:  :...::||     ....:.|.......::.::
Human   342 SLHFGTTHICGGTLIDAQWVLTAAHC---FF--VTREKVLEGWKVYAGTSNLHQLPEAASIAEII 401

  Fly   159 IHPKYSTRNFDSDIALIRFNEPVRLGIDMHPVCMPTPSENYA-GQTAVVTGWGALSE-GGPISDT 221
            |:..|:....|.||||:|.::|:.|...:||.|:|...:.:: .:|..:||:|...| ....|..
Human   402 INSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPF 466

  Fly   222 LQEVEVPILSQEECRNSNYGESKITDNMICAGYVEQGGKDSCQGDSGGPMHVLGSGDAYQLAGIV 286
            |:||:|.::..::|.:....:|.:|..|:|||.: :||:||||||||||: |....:.:.|||:.
Human   467 LREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDL-RGGRDSCQGDSGGPL-VCEQNNRWYLAGVT 529

  Fly   287 SWGEGCAKPNAPGVYTRVGSFNDWI 311
            |||.||.:.|.|||||:|.....||
Human   530 SWGTGCGQRNKPGVYTKVTEVLPWI 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	81/235 (34%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	82/236 (35%)
TMPRSS13	NP_001070731.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115
		13 X 5 AA repeats of A-S-P-A-[GLQR]	9..93
		4 X 5 AA repeats of T-P-P-G-R	14..68
		DUF3682	16..>87	CDD:289231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..157
		SRCR_2	231..320	CDD:292133	11/42 (26%)
		Tryp_SPc	325..554	CDD:214473	81/235 (34%)
		Tryp_SPc	326..557	CDD:238113	82/236 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42230
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910