DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and prss60.1

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_001082915.1	Gene:	prss60.1 / 799770	ZFINID:	ZDB-GENE-070424-25	Length:	387	Species:	Danio rerio

Alignment Length:	314	Identity:	105/314 - (33%)
Similarity:	159/314 - (50%)	Gaps:	32/314 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 CGNINTRHRIVGGQETEVHEYPWMIML--MWFGNFYCGASLVNDQYALTAAHCVNGFYHRLITVR 136
            ||.....:|||||.......:||.:.|  ..:|..:||.||:|.::.||||||:.......:.|.
Zfish    25 CGLAPLNNRIVGGVNAFDGSWPWQVSLHSPIYGGHFCGGSLINSEWVLTAAHCLPRITTSSLLVF 89

  Fly   137 LLEHNRQDSHVKIVDRRVSRVLIHPKYSTRNFDSDIALIRFNEPVRLGIDMHPVCMPTPSENYA- 200
            |.:..:|..:...::|.||.:.:||.|:....::||||:..:..|.....:.|||:...:..:.
Zfish    90 LGKTTQQGVNTYEINRTVSVITVHPSYNNLTNENDIALLHLSSAVTFSNYIRPVCLAAQNSVFPN 154

  Fly   201 GQTAVVTGWGALSEGG--PISDTLQEVEVPILSQEECRNSNYGESKITDNMICAGYVEQGGKDSC 263
            |.::.:||||.:..|.  |....|||..:|::..::| |:..|...:|:||||||.: |||:|:|
Zfish   155 GTSSWITGWGNIQLGVNLPAPGILQETMIPVVPNDQC-NALLGSGSVTNNMICAGLL-QGGRDTC 217

  Fly   264 QGDSGGPMHVLGSGDAYQLAGIVSWGEGCAKPNAPGVYTRVGSFNDWIAE------------NTR 316
            |||||||| |......:..:||.|||.|||.|.:|||||||..:..||..            |:.
Zfish   218 QGDSGGPM-VSKQCLVWVQSGITSWGYGCADPYSPGVYTRVSQYQSWINSIIVQNLPGFVLFNSS 281

  Fly   317 DAC---------SCAQPEAAGEPASPMETTEQGDQENTTANGAAEADPEVEEAN 361
            ..|         |.|.|.::...|||..||   ..:.:|.:.|:...|...:.:
Zfish   282 STCSSVSMTLPNSTALPTSSISTASPTTTT---TTKISTISSASTKPPTTSQTS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	88/233 (38%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	89/247 (36%)
prss60.1	NP_001082915.1	Tryp_SPc	33..264	CDD:214473	88/233 (38%)
		Tryp_SPc	34..267	CDD:238113	89/235 (38%)
		Somatomedin_B	349..382	CDD:295334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587887
Domainoid	1	1.000	191	1.000	Domainoid score	I3175
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3731
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6349
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.790