DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and ST14

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_068813.1	Gene:	ST14 / 6768	HGNCID:	11344	Length:	855	Species:	Homo sapiens

Alignment Length:	268	Identity:	104/268 - (38%)
Similarity:	153/268 - (57%)	Gaps:	22/268 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 KRECA------ECSCG--NINTRHRIVGGQETEVHEYPWMIMLMWFGNFY-CGASLVNDQYALTA 121
            |.:|:      :|.||  :...:.|:|||.:.:..|:||.:.|...|..: |||||::..:.::|
Human   590 KEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSA 654

  Fly   122 AHCV---NGFYH---RLITVRLLEHNR-QDSHVKIVDRRVSRVLIHPKYSTRNFDSDIALIRFNE 179
            |||.   .||.:   ...|..|..|:: |.|...:.:||:.|::.||.::...||.||||:...:
Human   655 AHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEK 719

  Fly   180 PVRLGIDMHPVCMPTPSENY-AGQTAVVTGWGALSEGGPISDTLQEVEVPILSQEECRNSNYGES 243
            |......:.|:|:|..|..: ||:...|||||....||..:..||:.|:.:::|..|  .|....
Human   720 PAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTC--ENLLPQ 782

  Fly   244 KITDNMICAGYVEQGGKDSCQGDSGGPM-HVLGSGDAYQLAGIVSWGEGCAKPNAPGVYTRVGSF 307
            :||..|:|.|:: .||.||||||||||: .|...|..:| ||:||||:|||:.|.||||||:..|
Human   783 QITPRMMCVGFL-SGGVDSCQGDSGGPLSSVEADGRIFQ-AGVVSWGDGCAQRNKPGVYTRLPLF 845

  Fly   308 NDWIAENT 315
            .|||.|||
Human   846 RDWIKENT 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	94/238 (39%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	95/240 (40%)
ST14	NP_068813.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SEA	88..>171	CDD:307516
		CUB	227..332	CDD:238001
		CUB	340..444	CDD:238001
		LDLa	454..486	CDD:238060
		LDLa	488..523	CDD:238060
		LDLa	525..559	CDD:238060
		LDLa	567..602	CDD:238060	2/11 (18%)
		Tryp_SPc	615..852	CDD:238113	95/240 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3952
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840