DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18735 and PRSS56

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_001356777.1	Gene:	PRSS56 / 646960	HGNCID:	39433	Length:	604	Species:	Homo sapiens

Alignment Length:	283	Identity:	112/283 - (39%)
Similarity:	151/283 - (53%)	Gaps:	16/283 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PAKRECAE--CSCGNINTRH-RIVGGQETEVHEYPWMIMLMWFGNFYCGASLVNDQYALTAAHCV 125
            |....|.|  .|..|:...| |||||.......:||::.|...|...||..||...:.||||||.
Human    83 PEPGPCGERRPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAAHCF 147

  Fly   126 NGFYHRLI-TVRLLEHNRQDSHVKIVDRRVSRVLIHPKYSTRNFDSDIALIRFNEPVRLGIDMHP 189
            .|..:.|: ||.|.|.:|.:...::   .|:|:|.|||:..|.|.:|:||::...||..|....|
Human   148 VGAPNELLWTVTLAEGSRGEQAEEV---PVNRILPHPKFDPRTFHNDLALVQLWTPVSPGGSARP 209

  Fly   190 VCMP-TPSENYAGQTAVVTGWGALSEGGPISDTLQEVEVPILSQEECRNSNYGESKITDNMICAG 253
            ||:| .|.|..||....:.|||||.|.||.::.::|..||:||.:.||.: .|.......|:|||
Human   210 VCLPQEPQEPPAGTACAIAGWGALFEDGPEAEAVREARVPLLSTDTCRRA-LGPGLRPSTMLCAG 273

  Fly   254 YVEQGGKDSCQGDSGGPMHVLGSGDAYQ--LAGIVSWGEGCAKPNAPGVYTRVGSFNDWIAENTR 316
            |: .||.||||||||||:.....|...:  |.|:.|||:||.:|..|||||||..|.||:.|...
Human   274 YL-AGGVDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVAVFKDWLQEQMS 337

  Fly   317 DACSCAQPEA----AGEPASPME 335
            .|.|..:|..    |.:|...::
Human   338 AASSSREPSCRELLAWDPPQELQ 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	99/232 (43%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	99/234 (42%)
PRSS56	NP_001356777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96		4/12 (33%)
		Tryp_SPc	105..335	CDD:238113	99/234 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001240
OrthoInspector	1	1.000	-	-		otm42230
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.810