DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	361	Identity:	100/361 - (27%)
Similarity:	164/361 - (45%)	Gaps:	75/361 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ALGDLAC------ATPSLRSAS-------DPEKILNNLAQLRQSSFLDWIQSILGPEVPAEWSSP 64
            ||.:.||      :.|:.|:..       |..:|..|..:||       :::..||.:.   .|.
Human   134 ALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELR-------MRNSSGPCLS---GSL 188

  Fly    65 AKRECAECSCGNINTRHRIVGGQETEVHEYPWMIMLMWFGNFYCGASLVNDQYALTAAHCVNGFY 129
            ....|  .:||......|:||.:|..|..:||.:.:.:.....||.|:::..:.||||||..
Human   189 VSLHC--LACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR--- 248

  Fly   130 HRLITVRLLEHNRQDSHVKIVDRR---------------VSRVLI---HPKYSTRNFDSDIALIR 176
                           .|..:.:.:               |::::|   :|.|..   |:||||::
Human   249 ---------------KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPK---DNDIALMK 295

  Fly   177 FNEPVRLGIDMHPVCMPTPSENYAGQTAV-VTGWGALSE-GGPISDTLQEVEVPILSQEECRNSN 239
            ...|:.....:.|:|:|...|.....|.: :.|||...: ||.:||.|.:..|.::....|...:
Human   296 LQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD 360

  Fly   240 YGESKITDNMICAGYVEQGGKDSCQGDSGGPMHVLGSGDAYQLAGIVSWGEGCAKPNAPGVYTRV 304
            ..:.::|:.|:||| :.:||.|:||||||||:  :...|.:.:.||||||.||..|:.|||||:|
Human   361 AYQGEVTEKMMCAG-IPEGGVDTCQGDSGGPL--MYQSDQWHVVGIVSWGYGCGGPSTPGVYTKV 422

  Fly   305 GSFNDWIAENTRDAC---SCAQPEAA---GEPASPM 334
            .::.:||....:|..   ||..|...   .:||.|:
Human   423 SAYLNWIYNVWKDRTIQRSCNSPGTGLVIQQPAVPL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	74/248 (30%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	75/250 (30%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	15/74 (20%)
		Tryp_SPc	204..429	CDD:214473	74/248 (30%)
		Tryp_SPc	205..432	CDD:238113	75/250 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3952
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940