DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and C1RL

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_057630.2	Gene:	C1RL / 51279	HGNCID:	21265	Length:	487	Species:	Homo sapiens

Alignment Length:	323	Identity:	90/323 - (27%)
Similarity:	139/323 - (43%)	Gaps:	67/323 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ATALGDLACATP-SLRSASDPEKILNNLAQLRQSSFLDWIQSILGPEVPAEWSSPAKRECAECSC 74
            |.|.|.|.|||| :.:...|.|::|                                 :|... |
Human   202 AAAAGALTCATPGTWKDRQDGEEVL---------------------------------QCMPV-C 232

  Fly    75 GN----INTRHRIVGGQETEVHEYPWMIMLMWFGNFYCGASLVNDQYALTAAHCVNGFYHRLITV 135
            |.    |......:|....::..:||.......|.  .|.:|:.|::.|||||.:  :....:::
Human   233 GRPVTPIAQNQTTLGSSRAKLGNFPWQAFTSIHGR--GGGALLGDRWILTAAHTI--YPKDSVSL 293

  Fly   136 R-------LLEHNRQDSHVKIVDRRVSRVLIHPKY---STRNFDSDIALIRFNEPVRLGIDMHPV 190
            |       .|.|...|..:|:.:..|.||::||.|   .:.||..||||:.....:.||.::.||
Human   294 RKNQSVNVFLGHTAIDEMLKLGNHPVHRVVVHPDYRQNESHNFSGDIALLELQHSIPLGPNVLPV 358

  Fly   191 CMPTPSENY-AGQTAVVTGWGALSEGGPISDTLQEVEVPILSQEECR---NSNYGESKITDNMIC 251
            |:|.....| :|....|:|:|  .|.|.::..|:...:|:..:|.|.   .........:|||.|
Human   359 CLPDNETLYRSGLLGYVSGFG--MEMGWLTTELKYSRLPVAPREACNAWLQKRQRPEVFSDNMFC 421

  Fly   252 AGYVEQGGKDS-CQGDSGGPMHVLGSGDAYQ--LAGIVSWGEGCAKPNAPGVYTRVGSFNDWI 311
            .|  ::..:.| ||||||. ::|:....|:.  ..||||||.||.:  ....||:|.|:.|||
Human   422 VG--DETQRHSVCQGDSGS-VYVVWDNHAHHWVATGIVSWGIGCGE--GYDFYTKVLSYVDWI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	73/245 (30%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	75/246 (30%)
C1RL	NP_057630.2	CUB	40..162	CDD:238001
		Tryp_SPc	247..480	CDD:238113	75/244 (31%)
		Tryp_SPc	247..479	CDD:214473	73/242 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910