DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and KLKB1

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	277	Identity:	100/277 - (36%)
Similarity:	147/277 - (53%)	Gaps:	37/277 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 CSCGN-----INTRHRIVGGQETEVHEYPWMIML---MWFGNFYCGASLVNDQYALTAAHCVNG- 127
            |:.|:     ..|..|||||..:...|:||.:.|   :......||.||:..|:.||||||.:|
Human   386 CNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGL 450

  Fly   128 -------FYHRLITVRLLEHNRQDSHVKIVDRRVSRVLIHPKYSTRNFDSDIALIRFNEPVRLGI 185
                   .|..::.:..:..:...|.:|       .::||..|.....:.|||||:...|:....
Human   451 PLQDVWRIYSGILNLSDITKDTPFSQIK-------EIIIHQNYKVSEGNHDIALIKLQAPLNYTE 508

  Fly   186 DMHPVCMPTPSENYAGQTAV------VTGWGALSEGGPISDTLQEVEVPILSQEECRNSNYGESK 244
            ...|:|:|:     .|.|:.      |||||...|.|.|.:.||:|.:|:::.|||: ..|.:.|
Human   509 FQKPICLPS-----KGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQ-KRYQDYK 567

  Fly   245 ITDNMICAGYVEQGGKDSCQGDSGGPMHVLGSGDAYQLAGIVSWGEGCAKPNAPGVYTRVGSFND 309
            ||..|:|||| ::||||:|:||||||: |......::|.||.|||||||:...|||||:|..:.|
Human   568 ITQRMVCAGY-KEGGKDACKGDSGGPL-VCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMD 630

  Fly   310 WIAENTRDACSCAQPEA 326
            ||.|.|:.:...||.::
Human   631 WILEKTQSSDGKAQMQS 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	91/245 (37%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	92/247 (37%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519	100/277 (36%)
		Tryp_SPc	401..632	CDD:214473	91/245 (37%)
		Tryp_SPc	402..632	CDD:238113	90/244 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42230
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810