Protein Alignment CG18735 and TMPRSS9

DIOPT Version :10

• Sequence 1: NP_652645.1
• Gene: CG18735 / 59137
• FlyBaseID: FBgn0042098
• Length: 364
• Species: Drosophila melanogaster
• Sequence 2: NP_001382442.1
• Gene: TMPRSS9 / 360200
• HGNCID: 30079
• Length: 1093
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 94/539 - (17%)
• Similarity: 177/539 - (32%)
• Gaps: 158/539 - (29%)

  Fly   814 GTVAAASASPLGP---------------SLTPPPVSGL----------------GTLVTSRAPGA 847
            |||..|...|..|               |..|..::||                .:.|..|..|.
Human   319 GTVVFAGYPPDVPQKLSCETHDLKEIICSWNPGRITGLVGPRNTEYTLFESISGKSAVFHRIEGL 383

  Fly   848 ETKYRQVNPSLVPGISTGNAAMFGSNNCAAQAILSRLSSAVARPTTAPAPAPAVPGAAPGLDRPP 912
            ..:..::...:.||....|..:.|.|.      |.:..|||....|... ||..|
Human   384 TNETYRLGVQMHPGQEIHNFTLTGRNP------LGQAQSAVVINVTERV-APHDP---------- 431

  Fly   913 GRSRLLEDFRNQRYPNLQLRDLTNHIVEFSQDQHGSRFIQQKLERAISV-----EKQLVFNEILG 972
                          .:|:::|:.:.:|.||....|: |.:..|...|.:     :|::....|.|
Human   432 --------------TSLKVKDINSTVVTFSWYLPGN-FTKINLLCQIEICKANSKKEVRNATIRG 481

  Fly   973 A---AYSLMTDVFGNYVI---------QKFFEFGS-PEQKQALAQQV---KG------------- 1008
            |   .|.:..|....|..         :.|:::.. .::|:.|..:.   ||
Human   482 AEDSTYHVAVDKLNPYTAYTFRVRCSSKTFWKWSRWSDEKRHLTTEATPSKGPDTWREWSSDGKN 546

  Fly  1009 ---HVLPLALQMYGCRVI------------QKALESIPAEQQQEIVRELDGHVLKCV-KDQNGNH 1057
               :..||.:.....:::            |..||....:.:.||....:.:::..| ::..|:.
Human   547 LIVYWKPLPINEANGKILSYNVSCSLNEETQSVLEIFDPQHRAEIQLSKNDYIISVVARNSAGSS 611

  Fly  1058 VVQKCIECV---DPVALQFIIDAFRNQVYSLSTHPYGCRVIQRILEHCTPEQTAPILAELHA--- 1116
            ...|.....   |.:.::..: ...|:::....|... .....:::.|...::.|.|.:...
Human   612 PPSKIASMEIPNDDITVEQAV-GLGNRIFLTWRHDPN-MTCDYVIKWCNSSRSEPCLLDWRKVPS 674

  Fly  1117 -NTEHLIQ-DQYGNYVIQHVLEHGKPEDKSALIASVRGKVLILSQHKFASNVVEKCVTHATRAER 1179
             :||.:|: ||:...|..:...:|.......|:.|:.|.|     .:.|..|........|.|:.
Human   675 NSTETVIESDQFQPGVRYNFYLYGCTNQGYQLLRSIIGYV-----EELAPIVAPNFTVEDTSADS 734

  Fly  1180 ALL------IEEVCSFNDSGLHVMMKDQ------------YANYVVQKMIDVSEPT------QRK 1220
            .|:      :||:..|....|....|.:            :::..::.:.|:|:.|      |.|
Human   735 ILVKWDDIPVEELRGFLRGYLFYFQKGERDTPKTRSLEPHHSDIKLKNITDISQKTLRIADLQGK 799

  Fly  1221 VLLHKIRPHMNSLKKYTYG 1239
            ...|.:      |:.||:|
Human   800 TSYHLV------LRAYTHG 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113
TMPRSS9	NP_001382442.1	SEA	66..>127	CDD:460188
		LDLa	188..223	CDD:238060
		Tryp_SPc	236..465	CDD:214473	35/177 (20%)
		Tryp_SPc	538..768	CDD:238113	37/236 (16%)
		Pneumo_att_G	<717..>867	CDD:114270	20/102 (20%)
		Tryp_SPc	861..1087	CDD:238113