DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and HP

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_005134.1	Gene:	HP / 3240	HGNCID:	5141	Length:	406	Species:	Homo sapiens

Alignment Length:	325	Identity:	95/325 - (29%)
Similarity:	147/325 - (45%)	Gaps:	69/325 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LRSASDPEKILNNLAQLRQSSFLDWIQSILGPEVPAEWSSPAKRECAECSCGN----INTRHRIV 84
            ||:..|....|||..|        ||...:|.::|         || |..||.    .|...||:
Human   117 LRTEGDGVYTLNNEKQ--------WINKAVGDKLP---------EC-EAVCGKPKNPANPVQRIL 163

  Fly    85 GGQETEVHEYPWMIMLMWFGNFYCGASLVNDQYALTAA------HCVNGFYHRLI-TVRLLEHNR 142
            ||.......:||...::...|...||:|:|:|:.||.|      |..|.....:. |:.|....:
Human   164 GGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKK 228

  Fly   143 QDSHVKIVDRRVSRVLIHPKYSTRNFDSDIALIRFNEPVRLGIDMHPVCMPTPSENYA--GQTAV 205
            |     :|:  :.:|::||.||    ..||.||:..:.|.:...:.|:|:  ||::||  |:...
Human   229 Q-----LVE--IEKVVLHPNYS----QVDIGLIKLKQKVSVNERVMPICL--PSKDYAEVGRVGY 280

  Fly   206 VTGWGALSEGGPISDTLQEVEVPILSQEEC----RNSNYGESK-----------ITDNMICAGYV 255
            |:|||. :.....:|.|:.|.:|:..|::|    ..|...|.|           :.::..||| :
Human   281 VSGWGR-NANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAG-M 343

  Fly   256 EQGGKDSCQGDSGG--PMHVLGSGDAYQLAGIVSWGEGCAKPNAPGVYTRVGSFNDW----IAEN 314
            .:..:|:|.||:|.  .:|.| ..|.:...||:|:.:.||.... |||.:|.|..||    ||||
Human   344 SKYQEDTCYGDAGSAFAVHDL-EEDTWYATGILSFDKSCAVAEY-GVYVKVTSIQDWVQKTIAEN 406

Fly 315 314
Human 407 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	74/258 (29%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	75/260 (29%)
HP	NP_005134.1	CCP	33..87	CDD:153056
		CCP	92..146	CDD:153056	13/46 (28%)
		Tryp_SPc	161..399	CDD:214473	73/254 (29%)
		Tryp_SPc	162..402	CDD:238113	73/256 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910