DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and F12

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_001014028.1	Gene:	F12 / 306761	RGDID:	1359175	Length:	603	Species:	Rattus norvegicus

Alignment Length:	322	Identity:	109/322 - (33%)
Similarity:	156/322 - (48%)	Gaps:	39/322 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CATPSLRSASDPE-----KILNNLAQLRQ----SSFLDWIQSILGPEVPAEWSSPAKRECAECSC 74
            |..|:|.|...||     |....:.|:.|    |..||  .|.....|.:..|:..   |.:...
  Rat   294 CQMPTLTSPVSPESHDMLKPRPPILQMPQFPSLSDALD--NSTRNQNVVSRTSTVV---CGQRFR 353

  Fly    75 GNINTRHRIVGGQETEVHEYPWMIMLMWFGNFYCGASLVNDQYALTAAHCVNGFYHRLITVRLLE 139
            ..:::..|:|||.......:|::..|.| |:.:|..||::..:.||||||:.   .|.....|..
  Rat   354 KRLSSLRRVVGGLVALPGSHPYIAALYW-GDSFCAGSLIDPCWVLTAAHCLQ---KRPAPEELTV 414

  Fly   140 HNRQDSHVKIVDR----RVSRVLIHPKYSTRNFDSDIALIRF----NEPVRLGIDMHPVCMPT-- 194
            ...||.|.:..:|    .|....:|..:|::.:..|:||:|.    |....|...:.|||:|:
  Rat   415 VLGQDRHNQSCERCQTLAVHSYRLHEGFSSKTYQHDLALLRLRGRKNSCAILSPHVQPVCLPSSA 479

  Fly   195 --PSENYAGQTAVVTGWGALSEGGPISDT-LQEVEVPILSQEECRNSNYGESKITDNMICAGYVE 256
              |||....:   |.|||...||.....| |||.:||.:|.:.|.:||.....|...|:|||::|
  Rat   480 APPSETVLCE---VAGWGHQFEGAEEYATFLQEAQVPFISLDRCSSSNVHGDAILPGMLCAGFLE 541

  Fly   257 QGGKDSCQGDSGGPMHVLGSGDAYQ---LAGIVSWGEGCAKPNAPGVYTRVGSFNDWIAENT 315
             ||.|:||||||||: |...|...:   |.|::|||.||...|.|||||.|.::.|||.|:|
  Rat   542 -GGADACQGDSGGPL-VCDEGVTERQLTLRGVISWGSGCGDRNKPGVYTDVANYLDWIQEHT 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	89/244 (36%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	90/246 (37%)
F12	NP_001014028.1	FN2	40..87	CDD:238019
		EGF_CA	95..130	CDD:238011
		FN1	132..170	CDD:238018
		EGF	177..207	CDD:278437
		Kringle	216..294	CDD:278480	109/322 (34%)
		Tryp_SPc	361..597	CDD:214473	89/244 (36%)
		Tryp_SPc	362..600	CDD:238113	90/246 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910