DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and F9

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_000124.1	Gene:	F9 / 2158	HGNCID:	3551	Length:	461	Species:	Homo sapiens

Alignment Length:	298	Identity:	95/298 - (31%)
Similarity:	150/298 - (50%)	Gaps:	48/298 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SASDPEKILNNLAQLRQSSFLDWIQSILGPEVPAEWSSPAKRECAECSCGNINTRHRIVGGQETE 90
            ::::.|.||:|:.|..||                                 .|...|:|||::.:
Human   203 NSTEAETILDNITQSTQS---------------------------------FNDFTRVVGGEDAK 234

  Fly    91 VHEYPWMIMLMWFGNFYCGASLVNDQYALTAAHCVNGFYHRLITVRLLEHNRQDSHVKIVDRRVS 155
            ..::||.::|....:.:||.|:||:::.:||||||.....  |||...|||.:::......|.|.
Human   235 PGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVK--ITVVAGEHNIEETEHTEQKRNVI 297

  Fly   156 RVLIHPKYST--RNFDSDIALIRFNEPVRLGIDMHPVCMPTPSENYAG-----QTAVVTGWGALS 213
            |::.|..|:.  ..::.||||:..:||:.|...:.|:|:  ..:.|..     .:..|:|||.:.
Human   298 RIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICI--ADKEYTNIFLKFGSGYVSGWGRVF 360

  Fly   214 EGGPISDTLQEVEVPILSQEECRNSNYGESKITDNMICAGYVEQGGKDSCQGDSGGPMHVLGSGD 278
            ..|..:..||.:.||::.:..|..|.  :..|.:||.|||: .:||:|||||||||| ||.....
Human   361 HKGRSALVLQYLRVPLVDRATCLRST--KFTIYNNMFCAGF-HEGGRDSCQGDSGGP-HVTEVEG 421

  Fly   279 AYQLAGIVSWGEGCAKPNAPGVYTRVGSFNDWIAENTR 316
            ...|.||:||||.||.....|:||:|..:.:||.|.|:
Human   422 TSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTK 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	83/235 (35%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	84/237 (35%)
F9	NP_000124.1	GLA	28..92	CDD:214503
		EGF_CA	93..129	CDD:238011
		FXa_inhibition	134..170	CDD:317114
		Tryp_SPc	227..457	CDD:238113	84/237 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910