DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and Tmprss4

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_663378.1	Gene:	Tmprss4 / 214523	MGIID:	2384877	Length:	435	Species:	Mus musculus

Alignment Length:	334	Identity:	103/334 - (30%)
Similarity:	154/334 - (46%)	Gaps:	73/334 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ALGDLAC------ATPSLRSAS-DPEKILNNLAQLRQSSFLDWIQSILGPEVPAEWSSPAKRECA 70
            ||...||      :.|:.|:.. .|::.| .:||:..:|....:|:             ..|.|.
Mouse   132 ALAKTACRQMGYDSQPAFRAVEIRPDQNL-PVAQVTGNSQELQVQN-------------GSRSCL 182

  Fly    71 ECS--------CGNINTRHRIVGGQETEVHEYPWMIMLMWFGNFYCGASLVNDQYALTAAHCVNG 127
            ..|        ||......|:|||.|..|..:||.:.:.:.....||.|:::..:.||||||
Mouse   183 SGSLVSLRCLDCGKSLKTPRVVGGVEAPVDSWPWQVSIQYNKQHVCGGSILDPHWILTAAHC--- 244

  Fly   128 FYHRLITVRLLEHNRQDSHVKIVDRRVSRVL------------------IHPKYSTRNFDSDIAL 174
             :.:.:.|         |..|:  |..|.:|                  ::||      :.||||
Mouse   245 -FRKYLDV---------SSWKV--RAGSNILGNSPSLPVAKIFIAEPNPLYPK------EKDIAL 291

  Fly   175 IRFNEPVRLGIDMHPVCMPTPSENYAGQTAV-VTGWGALSE-GGPISDTLQEVEVPILSQEECRN 237
            ::...|:.....:.|:|:|...|.....|.| |.|||...| ||.:||.|.:..|.::....|..
Mouse   292 VKLQMPLTFSGSVRPICLPFSDEVLVPATPVWVIGWGFTEENGGKMSDMLLQASVQVIDSTRCNA 356

  Fly   238 SNYGESKITDNMICAGYVEQGGKDSCQGDSGGPMHVLGSGDAYQLAGIVSWGEGCAKPNAPGVYT 302
            .:..|.::|..|:||| ..|||||:||||||||:  :...|.:|:.||||||.||..|:.|||||
Mouse   357 EDAYEGEVTAEMLCAG-TPQGGKDTCQGDSGGPL--MYHSDKWQVVGIVSWGHGCGGPSTPGVYT 418

  Fly   303 RVGSFNDWI 311
            :|.::.:||
Mouse   419 KVTAYLNWI 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	84/248 (34%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	85/249 (34%)
Tmprss4	NP_663378.1	LDLa	56..90	CDD:238060
		SRCR_2	106..195	CDD:295335	15/76 (20%)
		Tryp_SPc	202..427	CDD:214473	84/248 (34%)
		Tryp_SPc	203..430	CDD:238113	85/249 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3952
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940