DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and Klkb1

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_032481.2	Gene:	Klkb1 / 16621	MGIID:	102849	Length:	638	Species:	Mus musculus

Alignment Length:	336	Identity:	109/336 - (32%)
Similarity:	163/336 - (48%)	Gaps:	54/336 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CNFHLLLILATALGDLACATPSLRSASD--PEKILNNLA-----QLRQSSFLDWIQSILGPEVPA 59
            |.|.:..:|.....:..|.. |||.::|  |.:|...:.     .||....:|
Mouse   328 CQFFIYSLLPQDCKEEGCKC-SLRLSTDGSPTRITYGMQGSSGYSLRLCKLVD------------ 379

  Fly    60 EWSSPAKRECAECSCGNINTRHRIVGGQETEVHEYPWMIML---MWFGNFYCGASLVNDQYALTA 121
               ||      :|:. .||.  |||||....:.|:||.:.|   :......||.|::..|:.|||
Mouse   380 ---SP------DCTT-KINA--RIVGGTNASLGEWPWQVSLQVKLVSQTHLCGGSIIGRQWVLTA 432

  Fly   122 AHCVNG--------FYHRLITVRLLEHNRQDSHVKIVDRRVSRVLIHPKYSTRNFDSDIALIRFN 178
            |||.:|        .|..::::..:......|       |:..::||.:|.....:.|||||:..
Mouse   433 AHCFDGIPYPDVWRIYGGILSLSEITKETPSS-------RIKELIIHQEYKVSEGNYDIALIKLQ 490

  Fly   179 EPVRLGIDMHPVCMPTPSE-NYAGQTAVVTGWGALSEGGPISDTLQEVEVPILSQEECRNSNYGE 242
            .|:.......|:|:|:.:: |.......|||||...|.|...:.||:..:|::..|||: ..|.:
Mouse   491 TPLNYTEFQKPICLPSKADTNTIYTNCWVTGWGYTKEQGETQNILQKATIPLVPNEECQ-KKYRD 554

  Fly   243 SKITDNMICAGYVEQGGKDSCQGDSGGPMHVLGSGDAYQLAGIVSWGEGCAKPNAPGVYTRVGSF 307
            ..|...|||||| ::||.|:|:||||||:....|| .:||.||.|||||||:.:.|||||:|..:
Mouse   555 YVINKQMICAGY-KEGGTDACKGDSGGPLVCKHSG-RWQLVGITSWGEGCARKDQPGVYTKVSEY 617

  Fly   308 NDWIAENTRDA 318
            .|||.|.|:.:
Mouse   618 MDWILEKTQSS 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	87/240 (36%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	88/242 (36%)
Klkb1	NP_032481.2	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	201..284	CDD:128519
		APPLE	292..375	CDD:128519	12/47 (26%)
		Tryp_SPc	390..621	CDD:214473	87/240 (36%)
		Tryp_SPc	391..621	CDD:238113	86/239 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810