DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and PRSS36

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	336	Identity:	110/336 - (32%)
Similarity:	159/336 - (47%)	Gaps:	35/336 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LDWIQSILGPEVPAEWS----SPAKRECAECSCGNINTRHRIVGGQETEVHEYPWMIMLMWFGNF 106
            |..:..::.| :|..:.    ||.:.|..:..||......|||||...:...:||.:.|...|..
Human     7 LPLVMLVISP-IPGAFQDSALSPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGH 70

  Fly   107 YCGASLVNDQYALTAAHC--VNGF------YHRLITVRLLEHNRQDSHVKIVDRRVSRVLIHPKY 163
            .||.||:...:.|:||||  .||.      :..|:.|...:.....:|.    |.|:.:::...|
Human    71 ICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHT----RAVAAIVVPANY 131

  Fly   164 STRNFDSDIALIRFNEPVRLGIDMHPVCMPTPSENYAGQTAV-VTGWGALSEGG--PISDTLQEV 225
            |.....:|:||:|...|..||..:.|||:|..|..:...||. .||||.:.|..  |:...||||
Human   132 SQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEV 196

  Fly   226 EVPILSQE--ECRNSNYGESKIT----DNMICAGYVEQGGKDSCQGDSGGPMHVLGSGDAYQLAG 284
            |:.:|.:.  :|..|..|...:|    ..|:||||.| |.:|:||||||||: |...|..:..||
Human   197 ELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPE-GRRDTCQGDSGGPL-VCEEGGRWFQAG 259

  Fly   285 IVSWGEGCAKPNAPGVYTRVGSFNDWIAENTRDACSCAQPEAAGEPASPMETTEQGDQENTTANG 349
            |.|:|.||.:.|.|||:|.|.::..||.|....    ::|..| .|..|.:|  |.|.:......
Human   260 ITSFGFGCGRRNRPGVFTAVATYEAWIREQVMG----SEPGPA-FPTQPQKT--QSDPQEPREEN 317

  Fly   350 AAEADPEVEEA 360
            ...|.||..:|
Human   318 CTIALPECGKA 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	88/245 (36%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	89/247 (36%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	88/245 (36%)
		Tryp_SPc	47..289	CDD:238113	89/247 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316		7/30 (23%)
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810